Postoperatively administered aprotinin or epsilon aminocaproic acid after cardiopulmonary bypass has limited benefit Michael J Ray, PhD, Majella M Hales,

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Presentation transcript:

Postoperatively administered aprotinin or epsilon aminocaproic acid after cardiopulmonary bypass has limited benefit Michael J Ray, PhD, Majella M Hales, RN, Lee Brown, RN, Mark F O’Brien, E.Gregory Stafford The Annals of Thoracic Surgery Volume 72, Issue 2, Pages 521-526 (August 2001) DOI: 10.1016/S0003-4975(01)02819-3

Fig 1 Cumulative chest drainage volumes at 4-hour intervals for 24 hours postoperatively. Values in this and subsequent figures are expressed as medians and the error bars represent the 25th and 75th percentiles. ∗Difference between the aprotinin and placebo groups at that stage, p = 0.03. (EACA = epsilon aminocaproic acid.) The Annals of Thoracic Surgery 2001 72, 521-526DOI: (10.1016/S0003-4975(01)02819-3)

Fig 2 Cumulative chest drainage at 4-hour intervals for 24 hours postoperatively in those patients having valve operations in the aprotinin (n = 4) and placebo (n = 5) groups. ∗Difference between the aprotinin and placebo groups at those stages, p = 0.06. The Annals of Thoracic Surgery 2001 72, 521-526DOI: (10.1016/S0003-4975(01)02819-3)

Fig 3 Serum D-dimer levels at four stages. The levels were not statistically different at any stage. (EACA = epsilon aminocaproic acid.) The Annals of Thoracic Surgery 2001 72, 521-526DOI: (10.1016/S0003-4975(01)02819-3)

Fig 4 Changes in troponin I levels from those at pretreatment. Median (interquartile) pretreatment values were: aprotinin 4.2 ng/mL (2.7,7.5), epsilon aminocaproic acid (EACA) 3.8 ng/mL (2.5, 5.0), and placebo 2.4 ng/mL (1.8, 5.1). The Annals of Thoracic Surgery 2001 72, 521-526DOI: (10.1016/S0003-4975(01)02819-3)