Is early age at menarche a risk factor for endometriosis

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Presentation transcript:

Is early age at menarche a risk factor for endometriosis Is early age at menarche a risk factor for endometriosis? A systematic review and meta- analysis of case-control studies Kelechi E. Nnoaham, M.D., Premila Webster, M.D., Jharna Kumbang, M.D., Stephen H. Kennedy, M.R.C.O.G., Krina T. Zondervan, D.Phil. Fertility and Sterility Volume 98, Issue 3, Pages 702-712.e6 (September 2012) DOI: 10.1016/j.fertnstert.2012.05.035 Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Forest plot of 18 included studies evaluating association between early menarche and endometriosis. Fertility and Sterility 2012 98, 702-712.e6DOI: (10.1016/j.fertnstert.2012.05.035) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Meta-analysis of included studies presented by rigor of control for potential confounders. Fertility and Sterility 2012 98, 702-712.e6DOI: (10.1016/j.fertnstert.2012.05.035) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Scatter plot of Newcastle-Ottawa scale (NOS) score and study effect sizes. CI = confidence interval. Fertility and Sterility 2012 98, 702-712.e6DOI: (10.1016/j.fertnstert.2012.05.035) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 Funnel plot, using data from 18 case-control studies of early menarche and endometriosis risk, with effect sizes displayed on the horizontal axis. Fertility and Sterility 2012 98, 702-712.e6DOI: (10.1016/j.fertnstert.2012.05.035) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 3 Egger plot. CI = confidence interval. Fertility and Sterility 2012 98, 702-712.e6DOI: (10.1016/j.fertnstert.2012.05.035) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions