Chronic SSRI treatment rescued lOFC hyperactivity in QNP-treated mice.

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Chronic SSRI treatment rescued lOFC hyperactivity in QNP-treated mice. Chronic SSRI treatment rescued lOFC hyperactivity in QNP-treated mice. A, Time course of electrophysiological recordings combined with chronic SSRI administration. B, C, Current injection induced firing activity of lOFC pyramidal neurons in the absence (B) and presence (C) of GABAA antagonists. [B: water+QNP; n = 8 from 3 mice, Cit+QNP; n = 12 from 3 mice, two-way repeated measures ANOVA; drug (F(1,27.96) = 6.96, p = 0.0167), current (F(1.55,43.34) = 309.92, p < 0.0001), interaction (F(1.55,43.34) = 4.04, p = 0.0297), Bonferroni post hoc test; *p < 0.05 and **p < 0.01, C: water+QNP; n = 11 from 3 mice, Cit+QNP; n = 11 from 3 mice, two-way repeated measures ANOVA; drug (F(1,40.58) = 0.00, p = 0.9673), current (F(2.03,82.38) = 250.93, p < 0.0001), interaction (F(2.03,82.38) = 0.12, p = 0.8889).] D, Representative traces of sIPSCs and mIPSCs. E, F, sIPSC frequency (E) and amplitude (F) in lOFC pyramidal neurons. (Water+saline; n = 14 from 3 mice, water+QNP; n = 17 from 3 mice, Cit+QNP; n = 15 from 3 mice, E: one-way ANOVA; F(2,43) = 3.758, *p = 0.0313, Tukey’s multiple comparison test; *p < 0.05, F: one-way ANOVA; F(2,43) = 0.1188, p = 0.8883.) G, H, mIPSC frequency (G) and amplitude (H) in lOFC pyramidal neurons. (G: water+saline; n = 12 from 3 mice, water+QNP; n = 13 from 3 mice, Cit+QNP; n = 11 from 3 mice, one-way ANOVA; F(2,33) = 0.2934, p = 0.7476, H: water+saline; n = 12 from 3 mice, water+QNP; n = 11 from 3 mice, Cit+QNP; n = 10 from 3 mice, one-way ANOVA; F(2,30) = 0.1310, p = 0.8777.). Nozomi Asaoka et al. eNeuro 2019;6:ENEURO.0366-18.2019 ©2019 by Society for Neuroscience