Mediastinal lymph node dissection improves survival in patients with stages II and IIIa non-small cell lung cancer Steven M Keller, MD, Sudeshna Adak,

Slides:

Advertisements

Similar presentations

Ricardo L. Oliveira, MD, Moishe Liberman, MD, PhD

Advertisements

Elizabeth A. David, MD, David T

Jeffrey L. Port, MD, Robert J. Korst, MD, Paul C. Lee, MD, Amanda L

Survival After Surgical Resection for Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease Anders Bugge, MD, May Brit Lund, MD, PhD, Cathrine.

Complete Thoracic Mediastinal Lymphadenectomy Leads to a Higher Rate of Pathologically Proven N2 Disease in Patients With Non-Small Cell Lung Cancer

Comparison of Thoracoscopic Segmentectomy and Thoracoscopic Lobectomy for Small-Sized Stage IA Lung Cancer Chenxi Zhong, MD, Wentao Fang, MD, Teng Mao,

Prognostic Significance of the Number of Lymph Nodes Removed at Lobectomy in Stage IA Non-small Cell Lung Cancer Sai-Hong Ignatius Ou, MD, PhD, Jason.

Rodrigo A. S. Sardenberg, MD, Clovis Pinto, MD, Cynthia A

Missed Intrapulmonary Lymph Node Metastasis and Survival After Resection of Non- Small Cell Lung Cancer Matthew P. Smeltzer, PhD, Nicholas Faris, MDiv,

Joshua E. Rosen, BASc, Hari B

Standard Uptake Value Predicts Survival in Non–Small Cell Lung Cancer

Tumor Necrosis as a Prognostic Factor for Stage IA Non-Small Cell Lung Cancer Seong Yong Park, MD, Hyun-Sung Lee, MD, PhD, Hee-Jin Jang, MD, Geon Kook.

Significance of P53 and Rb protein expression in surgically treated non-small cell lung cancers Yung-Chie Lee, MD, PhD, Yih-Leong Chang, MD, Shi-Ping.

Lung cancer staging and treatment in multidisciplinary trials: cancer and leukemia group B cooperative group approach1 Mark J Krasna, MD, Carolyn E Reed,

Oncologic Outcomes After Surgical Resection of Subcentimeter Non-Small Cell Lung Cancer Matthew J. Schuchert, MD, Arman Kilic, BS, Arjun Pennathur, MD,

Lisa M. Brown, MD, MAS, David T. Cooke, MD, Elizabeth A. David, MD

Clinical Prognosis of Superior Versus Basal Segment Stage I Non-Small Cell Lung Cancer Yoshinori Handa, MD, Yasuhiro Tsutani, MD, PhD, Norifumi Tsubokawa,

Sarcoid-Like Reaction Mimics Progression of Disease After Induction Chemotherapy for Lung Cancer Masayuki Chida, MD, PhD, Takashi Inoue, MD, Koichi Honma,

Morbidity, Survival, and Site of Recurrence After Mediastinal Lymph-Node Dissection Versus Systematic Sampling After Complete Resection for Non-Small.

Osteopontin Combined With CD44v6, a Novel Prognostic Biomarker in Non-Small Cell Lung Cancer Undergoing Curative Resection Bing-sheng Sun, MD, PhD, Yue.

Video-Assisted Thoracic Surgery Lobectomy: Experience With 1,100 Cases

Non-Small Cell Lung Cancer Resection in Lymphoma Patients

David T. Cooke, MD, Danh V. Nguyen, PhD, Ying Yang, MS, Steven L

Lymph Node Evaluation Achieved by Open Lobectomy Compared With Thoracoscopic Lobectomy for N0 Lung Cancer Robert E. Merritt, MD, Chuong D. Hoang, MD,

Osteopontin-Expressing Macrophages in Non-Small Cell Lung Cancer Predict Survival Yue Li, MD, Bing-sheng Sun, MD, PhD, Baoxiang Pei, MD, Chen-guang Li,

Prognostic Predictors in Non-Small Cell Lung Cancer Patients Undergoing Intentional Segmentectomy Terumoto Koike, MD, PhD, Teruaki Koike, MD, PhD, Yasushi.

Brendon M. Stiles, MD, Farooq Mirza, MD, Jeffrey L. Port, MD, Paul C

Surgical Treatment of Metachronous Second Primary Lung Cancer

Lobe-specific extent of systematic lymph node dissection for non–small cell lung carcinomas according to a retrospective study of metastasis and prognosis

Asad A. Shah, MD, Mathias Worni, MD, MHS, Christopher R

Ricardo L. Oliveira, MD, Moishe Liberman, MD, PhD

Large cell neuroendocrine carcinoma and large cell carcinomas with neuroendocrine morphology of the lung: prognosis after complete resection and systematic.

Bilobectomy for Lung Cancer: Analysis of Indications, Postoperative Results, and Long- Term Outcomes Domenico Galetta, MD, PhD, Piergiorgio Solli, MD,

Elliot Wakeam, MD, MPH, James P. Byrne, MD, Gail E

Recurrence and Survival After Segmentectomy in Patients With Prior Lung Resection for Early-Stage Non-Small Cell Lung Cancer Lisa M. Brown, MD, Brian.

The Prognostic Value of the Number of Negative Lymph Nodes in Esophageal Cancer Patients After Transthoracic Resection Po-Kuei Hsu, MD, Chien-Sheng Huang,

Andrew P. Dhanasopon, MD, Michelle C. Salazar, MD, Jessica R

Differences in Patterns of Recurrence in Early-Stage Versus Locally Advanced Non- Small Cell Lung Cancer Feiran Lou, MD, MS, Camelia S. Sima, MD, MS,

Results of surgical intervention for p-stage IIIA (N2) non–small cell lung cancer: Acceptable prognosis predicted by complete resection in patients with.

Prolonged survival in patients with resected non–small cell lung cancer and single-level N2 disease Steven M Keller, MD, Mark G Vangel, PhD, Henry Wagner,

Valerie W Rusch, MD, Ennapadam S Venkatraman, PhD

Importance of Lymph Node Dissection in Thymic Carcinoma

Selective Mediastinal Lymphadenectomy for Clinico-Surgical Stage I Non–Small Cell Lung Cancer Morihito Okada, MD, PhD, Toshihiko Sakamoto, MD, PhD, Tsuyoshi.

Pathologic N1 non-small cell lung cancer: Correlation between pattern of lymphatic spread and prognosis Alessandro Marra, MD, PhD, Ludger Hillejan, MD,

Lymph Node Assessment and Impact on Survival in Video-Assisted Thoracoscopic Lobectomy or Segmentectomy Haiyu Zhou, MD, Luis F. Tapias, MD, Henning A.

Jonathan D. Spicer, MD, PhD, Jitesh B. Shewale, BDS, PhD, David B

Superior and Basal Segment Lung Cancers in the Lower Lobe Have Different Lymph Node Metastatic Pathways and Prognosis Shun-ichi Watanabe, MD, Kenji Suzuki,

Radiofrequency Ablation for Stage I Non-Small Cell Lung Cancer: Management of Locoregional Recurrence Michael Lanuti, MD, Amita Sharma, MD, Henning Willers,

Douglas E. Paull, MD, Glenda M. Updyke, PA-C, Michael A

Value of systematic mediastinal lymph node dissection during pulmonary metastasectomy Florian Loehe, MD, Sonja Kobinger, MD, Rudolf A Hatz, MD, Thomas.

Arman Kilic, BS, Matthew J. Schuchert, MD, Brian L

Lewis Y antigen expression and postoperative survival in non–small cell lung cancer Fumihiro Tanaka, MD, Ryo Miyahara, MD, Yohsuke Ohtake, MD, Kazuhiro.

A Strategy for Determining Which Thoracic Esophageal Cancer Patients Should Undergo Cervical Lymph Node Dissection Shiro Nagatani, MD, Yutaka Shimada,

Carcinoma of the esophagus: Prognostic significance of histologic type

Prognostic Significance of Aberrant Methylation of Solute Carrier Gene Family 5A8 in Lung Adenocarcinoma Koei Ikeda, MD, PhD, Kenji Shiraishi, MD, PhD,

Visceral Pleural Invasion Is Not Predictive of Survival in Patients With Lung Cancer and Smaller Tumor Size Elizabeth David, MD, Peter F. Thall, PhD,

Predictors of Survival After Operation Among Patients With Large Cell Neuroendocrine Carcinoma of the Lung Florian Eichhorn, MD, Hendrik Dienemann, MD,

Mara B. Antonoff, MD, Wayne L. Hofstetter, MD, Arlene M

James D Luketich, Michael E Burt The Annals of Thoracic Surgery

Shared Decision Making and Effective Risk Communication in the High-Risk Patient With Operable Stage I Non-Small Cell Lung Cancer Pamela Samson, MD,

Neal S Goldstein, MD The Annals of Thoracic Surgery

Relevance of Lymph Node Micrometastases in Radically Resected Endobronchial Carcinoid Tumors Tommaso Claudio Mineo, MD, Gianluca Guggino, MD, Davide.

Effect of Formalin Fixation on Tumor Size Determination in Stage I Non-Small Cell Lung Cancer Po-Kuei Hsu, MD, Hsu-Chih Huang, MD, Chih-Cheng Hsieh,

Survival and Outcomes of Pulmonary Resection for Non-Small Cell Lung Cancer in the Elderly: A Nested Case-Control Study Robert J. Cerfolio, MD, Ayesha.

Mark I. Block, MD The Annals of Thoracic Surgery

Congenital absence of the right upper lobe of the lung

Prognostic factors for survival after pulmonary resection of metastatic renal cell carcinoma Joachim Pfannschmidt, MD, Hans Hoffmann, MD, PhD, Thomas.

Early Surgical Results After Pneumonectomy for Non-Small Cell Lung Cancer are not Affected by Preoperative Radiotherapy and Chemotherapy Tomas Gudbjartsson,

A phase II single-institution study of neoadjuvant stage IIIA/B chemotherapy and radiochemotherapy in non-small cell lung cancer Andreas Granetzny, MD,

Video-Assisted Thoracoscopic Surgery Is a Safe and Effective Alternative to Thoracotomy for Anatomical Segmentectomy in Patients With Clinical Stage I.

Presentation transcript:

Mediastinal lymph node dissection improves survival in patients with stages II and IIIa non-small cell lung cancer Steven M Keller, MD, Sudeshna Adak, PhD, Henry Wagner, MD, David H Johnson, MD The Annals of Thoracic Surgery Volume 70, Issue 2, Pages 358-365 (August 2000) DOI: 10.1016/S0003-4975(00)01673-8

Fig 1 One hundred ninety-two surgeons accrued patients to the study. The majority entered only 1 patient. The Annals of Thoracic Surgery 2000 70, 358-365DOI: (10.1016/S0003-4975(00)01673-8)

Fig 2 Survival. Patients who underwent complete MLND survived significantly longer than those patients who underwent SS. The Annals of Thoracic Surgery 2000 70, 358-365DOI: (10.1016/S0003-4975(00)01673-8)

Fig 3 Survival with N1 disease. The median survival of patients with N1 disease was significantly prolonged if they had a complete MLND. The Annals of Thoracic Surgery 2000 70, 358-365DOI: (10.1016/S0003-4975(00)01673-8)

Fig 4 Survival with N2 disease. The survival advantage for patients who had undergone complete MLND was also present for those patients with N2 disease. The Annals of Thoracic Surgery 2000 70, 358-365DOI: (10.1016/S0003-4975(00)01673-8)

Fig 5 Right lung tumors. The improved survival with complete MLND was limited to right lung cancers and was present for both upper and lower lobe tumors. The Annals of Thoracic Surgery 2000 70, 358-365DOI: (10.1016/S0003-4975(00)01673-8)

Fig 6 Left lung tumors. The type of lymph node dissection did not influence the survival of patients with left lung cancers regardless of whether the tumor originated in the upper (log rank test, p = 0.90) or lower lobes (log rank test, p = 0.89). The Annals of Thoracic Surgery 2000 70, 358-365DOI: (10.1016/S0003-4975(00)01673-8)

Fig 7 Disease-free survival, right lung tumors. Median disease-free survival was significantly prolonged in patients with right lung tumors who underwent complete MLND compared with those who underwent SS. The Annals of Thoracic Surgery 2000 70, 358-365DOI: (10.1016/S0003-4975(00)01673-8)