Effect of IBMP and PKG on cAMP levels

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Effect of IBMP and PKG on cAMP levels Effect of IBMP and PKG on cAMP levels.A, Effect of PKG and PKG-specific inhibitor on odorant-induced cAMP production. Effect of IBMP and PKG on cAMP levels.A, Effect of PKG and PKG-specific inhibitor on odorant-induced cAMP production. IBMP (0.1 μm) was applied for 2 min to cilia, with or without 60 μm PKG and 20 μm PKG inhibitor, KT5823. The isolated olfactory cilia were incubated with PKG for 15 min before assay at room temperature. Results are presented as percentage of control ± SEM.B, Dose-dependency of cAMP production on PKG concentration in isolated rat olfactory cilia. PKG was incubated with the olfactory cilia at concentrations from 0 to 250 μm in the presence of 0.1 μm IBMP applied for 2 sec. To inhibit PDE activity, 0.5 mm IBMX was added. Cheil Moon et al. J. Neurosci. 1998;18:3195-3205 ©1998 by Society for Neuroscience