Hyperthermia-induced ATF2 and NFκB phosphorylation is p38-MAPK mediated. Hyperthermia-induced ATF2 and NFκB phosphorylation is p38-MAPK mediated. The effect.

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Hyperthermia-induced ATF2 and NFκB phosphorylation is p38-MAPK mediated. Hyperthermia-induced ATF2 and NFκB phosphorylation is p38-MAPK mediated. The effect of SB203580 on hyperthermia-induced phosphorylation levels of cJun (A), ATF2 (B) and NFκB (C) was assessed in nuclear fractions from gill tissue extracts (30 μg) from control animals (15°C) and animals exposed to hyperthermia (30°C) for 30 min (cJun, ATF2) or 60 min (NFκB). Equal protein loading was confirmed by blotting identical samples with an anti-histone H1 specific antibody (D). Bands were quantified by laser scanning densitometry (respective graphs). Blots and results shown are representative of at least four independent experiments. Results are means ± s.e. for at least four independent experiments. *P<0.01 compared with identically treated animals in the absence of the respective inhibitor. E. Gourgou et al. J Exp Biol 2010;213:347-357 © 2010.