GTTs and ITTs. A: GTTs of WT (◇), LepTg (♦), Akita (open circles), and LepTg:Akita (closed circles) mice at 8 and 16 weeks of age. GTTs and ITTs. A: GTTs.

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Volume 4, Issue 12, Pages (December 2015)

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GTTs and ITTs. A: GTTs of WT (◇), LepTg (♦), Akita (open circles), and LepTg:Akita (closed circles) mice at 8 and 16 weeks of age. GTTs and ITTs. A: GTTs of WT (◇), LepTg (♦), Akita (open circles), and LepTg:Akita (closed circles) mice at 8 and 16 weeks of age. Blood glucose levels are shown at indicated times after glucose injections (1 g/kg body wt i.p.; n ≥4 in each group). B: ITTs of WT (◇), LepTg (♦), Akita (○), and LepTg:Akita (●) mice at 8, 18, and 28 weeks of age. Percent changes in blood glucose levels are shown at indicated times after injection of insulin (0.5 units/kg body wt i.p.; n ≥ 4 in each group). Dashed line indicates detection limit of 600 mg/dL. Data are expressed as means ± SE. §P < 0.05, §§P < 0.01 for WT vs. Akita, ‡P < 0.05, ‡‡P < 0.01 for WT vs. LepTg:Akita, ★P < 0.05, ★★P < 0.01 for LepTg vs. LepTg:Akita, *P < 0.05, and **P < 0.01 for Akita vs. LepTg:Akita. Masaki Naito et al. Diabetes 2011;60:2265-2273 ©2011 by American Diabetes Association