CD34+ cell content of 126 341 cord blood units in the US inventory: implications for transplantation and banking by Juliet N. Barker, Jane Kempenich, Joanne.

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Presentation transcript:

CD34+ cell content of 126 341 cord blood units in the US inventory: implications for transplantation and banking by Juliet N. Barker, Jane Kempenich, Joanne Kurtzberg, Claudio G. Brunstein, Colleen Delaney, Filippo Milano, Ioannis Politikos, Elizabeth J. Shpall, Andromachi Scaradavou, and Jason Dehn BloodAdv Volume 3(8):1267-1271 April 23, 2019 © 2019 by The American Society of Hematology

Juliet N. Barker et al. Blood Adv 2019;3:1267-1271 © 2019 by The American Society of Hematology

Distribution of the CD34:TNC ratio of CB units in the domestic CB unit inventory. Distribution of the CD34:TNC ratio of CB units in the domestic CB unit inventory. A total of 23 units with ratios of 3.0 to 30.9 are excluded from this figure. Juliet N. Barker et al. Blood Adv 2019;3:1267-1271 © 2019 by The American Society of Hematology

Potential units that are adequately dosed for a 70-kg patient. Potential units that are adequately dosed for a 70-kg patient. Suitable units for a single-unit graft (TNC dose, ≥2.5 × 107/kg; CD34+ cell dose, ≥1.5 × 105/kg) represent 4% of the inventory (smaller panel). Units that would be suitable as 1 of 2 for a double-unit graft (TNC dose, ≥1.5 × 107/kg; CD34+ cell dose, ≥1.0 × 105/kg per unit) represent 22% of the inventory (larger panel). Juliet N. Barker et al. Blood Adv 2019;3:1267-1271 © 2019 by The American Society of Hematology