Short-term synaptic depression in SCN neurons during stimulus train application. Short-term synaptic depression in SCN neurons during stimulus train application.

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Short-term synaptic depression in SCN neurons during stimulus train application. Short-term synaptic depression in SCN neurons during stimulus train application. Stimulation of the optic chiasm with trains of 25 stimuli at 0.08- to 25-Hz frequencies (A–F). The amplitude of each subsequent eEPSC in the train was normalized to the amplitude of the first eEPSC: eEPSCn/eEPSC1. Frequency-dependence changes of eEPSC amplitude in WT (n = 18 neurons), control (Opn4+/+; Vglut2loxP/loxP; n = 16 neurons), cKO (Opn4Cre/+; Vglut2loxP/loxP; n = 8 neurons), and dKO (Opn4Cre/Cre; Vglut2loxP/loxP; n = 2 neurons) mice during stimulation with frequencies ranging from 0.08 to 25 Hz. Michael G. Moldavan et al. eNeuro 2018;5:ENEURO.0411-17.2018 ©2018 by Society for Neuroscience