Michael F. Gurish, PhD, Joshua A. Boyce, MD

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Mast cells: Ontogeny, homing, and recruitment of a unique innate effector cell Michael F. Gurish, PhD, Joshua A. Boyce, MD Journal of Allergy and Clinical Immunology Volume 117, Issue 6, Pages 1285-1291 (June 2006) DOI: 10.1016/j.jaci.2006.04.017 Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Morphologic characteristics of cells arising from cytofluorographically isolated GMPs from bone marrow of C57BL/6 mice. The depicted cells arose from the culture of a single GMP in the presence of SCF, IL-3, IL-5, IL-6, and IL-9, giving rise to a colony containing both MCs and basophils (Ba), as well as monocytes, neutrophils (neutro), and other granulocytes. Magnification 1000×. Journal of Allergy and Clinical Immunology 2006 117, 1285-1291DOI: (10.1016/j.jaci.2006.04.017) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Cytofluorographic sorting of intestinal MCPs. The CD45+, lineage marker–negative (left), CD34+ (center) subpopulation of mononuclear cells from mouse intestine were sorted for high expression of β7 integrin and FcεRI (right) and stained with hematoxylin and eosin before (lower left) and after (lower right) culture in the presence of myeloerythroid cytokines16 for 7 days. This cell population gives rise only to pure colonies of MCs. Magnification = 1000×. FSC, Forward scatter. Journal of Allergy and Clinical Immunology 2006 117, 1285-1291DOI: (10.1016/j.jaci.2006.04.017) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Cytofluorographic sorting and characterization of splenic BMCPs and bone marrow BaPs. A, Lineage marker–negative, c-kit+, FcγRII/III+, β7hi, FcεRIlo spleen cells stained before (left) and after (right) culture. Only 3 colony types arise; pure MCs, pure basophils (Ba), and colonies containing both basophils and MCs (right). B, Only 2 populations arise in cultures of splenic β7hi, FcεRIlo cells, which differ in their expression of c-kit (bottom left) and are characterized as BaPs or MCPs (right). C, BaPs, but not MCPs, are identified in the bone marrow and are identical to cells arising from splenic BMCPs. Magnification = 1000×. Journal of Allergy and Clinical Immunology 2006 117, 1285-1291DOI: (10.1016/j.jaci.2006.04.017) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 Mouse MC differentiation pathway. MC development in C57BL/6 mice proceeds along the myeloid pathway through the CMPs and then through the GMPs. In the bone marrow GMPs are the immediate precursor of the MCPs and BaPs. BMCPs are found exclusively in the spleen and differentiate into both MCPs and BaPs on culture in myeloid growth factors. HSC, Hematopoietic stem cell; CLP, common lymphoid progenitor; MEP, megakaryocyte erythrocyte progenitor; NK cell, natural killer cell. Journal of Allergy and Clinical Immunology 2006 117, 1285-1291DOI: (10.1016/j.jaci.2006.04.017) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions