Intracellular electrical recordings from islet β-cells exhibiting three types of oscillations. Intracellular electrical recordings from islet β-cells exhibiting.

Slides:

Advertisements

Similar presentations

Tutorial: Electrophysiology of Pancreatic Islets Richard Bertram Department of Mathematics and Programs in Neuroscience and Molecular Biophysics Florida.

Advertisements

The Dual Oscillator Model for Pancreatic Islets Richard Bertram Department of Mathematics and Programs in Neuroscience and Molecular Biophysics Florida.

ANUP UMRANIKAR A Phantom Bursting Mechanism for Episodic Bursting Richard Bertram, Joseph Rhoads, Wendy Cimbora.

تاثیر هورمون IBA و BAP بر روی ریشه های جانبی وجوانه زایی گل رز

Glucose homeostasis: roles of insulin and glucagon. 1A.

The prevalence of diabetes (A), impaired glucose tolerance (B), impaired fasting glucose (C), and impaired glucose metabolism (D) among those with Finnish.

Nat. Rev. Endocrinol. doi: /nrendo

A: Percentage of type 1 diabetic and type 2 diabetic patients with asymptomatic hypoglycemias detected by the CGMS. B: Daily distribution of asymptomatic.

Volume 110, Issue 3, Pages (February 2016)

Modeling of Glucose-Induced cAMP Oscillations in Pancreatic β Cells: cAMP Rocks when Metabolism Rolls Bradford E. Peercy, Arthur S. Sherman, Richard.

Percentages of children with autoimmune type 1 diabetes who carried the TCF7L2 rs TT genotype, expressed ICA512/IA2 or ZnT8 autoantibodies, presented.

Functional characteristics of neutrophils prior to and following (phorbol myristate acetate) PMA stimulation. Functional characteristics of neutrophils.

Catherine M. Pound et al. Hospital Pediatrics 2017;7:

MRNA expression levels of the gene encoding CAR in isolated human islets from control donors, cultured for prolonged time (n=2). mRNA expression levels.

Representative images of human islets infected with strains of CVB

Pitx3-GFP+ cells exhibit functional neuron-like electrophysiological properties. Pitx3-GFP+ cells exhibit functional neuron-like electrophysiological properties.

Cyp8b1−/− mice have improved islet insulin secretion and increased islet insulin content but unchanged β-cell mass. Cyp8b1−/− mice have improved islet.

Involvement of IRS-1 in L-783,281–stimulated increases in [Ca2+]i and exocytosis. Involvement of IRS-1 in L-783,281–stimulated increases in [Ca2+]i and.

Mean (95% CI) fasting s-glucose at baseline and 6-month, 12-month, and 24-month follow-up, overall and by sex (A), and by baseline age (B), education (C),

Decreased GLP-1 receptor expression in islets after exposure to high glucose. Decreased GLP-1 receptor expression in islets after exposure to high glucose.

1018-NT-β-cell clusters protect mice from STZ-induced diabetes.

GSIS. GSIS. In vivo: serum insulin levels at fasting state and 30 min after glucose injection (A) and the fold change in serum insulin after glucose loading.

Glucose infusion rate required to maintain the hyperglycemic clamp during the experimental period in sedentary and exercised dogs receiving basal or elevated.

Effect of PIs on insulin release by downstream insulin secretogogues.

Human and mouse islets express MCH and MCHR1.

Cell proliferations, ROS production, and ATP levels in HASMCs cultured under high-glucose condition. Cell proliferations, ROS production, and ATP levels.

Glycemia and glucose tolerance of RIP-N mice.

Attenuation of glucose-, ex-4–, and GIP-induced increases in NSCC current in β-cells from TRPM2-KO mice. Attenuation of glucose-, ex-4–, and GIP-induced.

Immune cell activation detected by gene expression in representative pancreatic islets of IDDM rats after successful combination therapy with anti–TNF-α.

A single dose of liraglutide (Lira) (7. 5 μg/kg or 0

Zn2+ and NAD(P)H content in Mafa∆panc and Mafa∆panc;Mafb+/− β-cells.

IRS-1 and -2 expression in four mesangial cell lines from different D-NOD (A and B) and ND-NOD (C and D) mice. IRS-1 and -2 expression in four mesangial.

T2D loci stratified by patterns of quantitative trait (e. g

Diabetes intervention (ACM) and control (TTR-only) care package details. ACM = additional case management. BP = blood pressure. FBG = fasting blood glucose.

Grg3 is expressed in most β-cells but less frequently in α-cells.

A and B: Intracellular cAMP levels and lipolysis in adipocytes from chow-fed and HFD-fed mice. A and B: Intracellular cAMP levels and lipolysis in adipocytes.

Continuous associations

Starvation-induced inhibition of leptin transport across the BBB is caused by a circulating factor. Starvation-induced inhibition of leptin transport across.

Somatostatin released by δ-cells exerts a tonic inhibition on glucagon and insulin secretion but is not required for the glucagonostatic effect of glucose.

Effect of blockade of the Fas receptor on glucose- and interleukin-1β–induced β-cell DNA fragmentation and proliferative activity. Effect of blockade of.

BAFF-deficient (BAFFnull) and anti-BAFF antibody (Ab)–treated obese mice exhibit superior glucose metabolic control compared with WT and Bnull mice. BAFF-deficient.

A-N: Immunofluorescence analysis of Bcl family genes in human islets of Langerhans. A-N: Immunofluorescence analysis of Bcl family genes in human islets.

Insulitis is reduced in CT-treated RIP-LCMV-GP mice.

Involvement of PKCα in downregulation of GLP-1 receptor by high glucose in isolated rat islets. Involvement of PKCα in downregulation of GLP-1 receptor.

Chop deletion preserves β-cell function in P58IPK−/− mice.

COX-2 deletion in macrophages led to increased renal macrophage infiltration in diabetic mice. COX-2 deletion in macrophages led to increased renal macrophage.

Hashimoto et al. Hashimoto et al. (10) provide the data that insulin produced by β-cells is important for the maintenance of islet blood perfusion, and.

ChREBPα increases β-cell mitochondrial activity and ATP production in human islets. ChREBPα increases β-cell mitochondrial activity and ATP production.

The lack of effect of denatonium to stimulate insulin release in the absence of extracellular Ca2+ or in the presence of 10 μmol/l nitrendipine. The lack.

A: Southern blot analysis of UCP-2 and GAPDH PCR products amplified from equal amounts of pancreatic islet total RNA isolated from control (n = 7) and.

Expression of PKCδ in islets and other tissues of control and PKCδKN-overexpressing mice. Expression of PKCδ in islets and other tissues of control and.

PKA inhibitors do not markedly affect the potentiation of glucose-induced insulin release by GLP-1. PKA inhibitors do not markedly affect the potentiation.

Loss of Phb2 in β-cells induces development of diabetes over a 3-week period in β-Phb2−/− mice. Loss of Phb2 in β-cells induces development of diabetes.

RT-PCR quantification of ubiquitination gene transcripts in rat islets exposed to 2.8 or 16.7 mmol/l glucose for 2 h (A) or 24 h (B). RT-PCR quantification.

Comparison of the percentages of ducts in the pancreas containing cells showing positive staining for the different markers between control patients and.

Apoptosis in CAM vessels after staining with TUNEL

Chronic rapamycin treatment impairs β-cell mass and insulin clearance in rats. Chronic rapamycin treatment impairs β-cell mass and insulin clearance in.

ADCY5 targets nonmetabolic processes to alter Ca2+ responses.

Relationship between changes in mean fat cell volume and insulin sensitivity (M values) after gastric bypass of obese women. Relationship between changes.

Pooled analysis of association between (nonexclusive) breast-feeding and childhood-onset type 1 diabetes in studies investigating ∼2 weeks (nonexclusive)

The hyperbolic relationship between fasting insulin and Si (A) and AIRg and Si (B) for NFG (FPG

A: Typical course of a normal sympathetic vasomotor response as recorded by continuous wave Doppler sonography. A: Typical course of a normal sympathetic.

Schematic representation of the control of muscle glucose uptake during exercise. Schematic representation of the control of muscle glucose uptake during.

SBC-5 miR-335+, but not SBC-5 miR-29a+, exhibited reduced IGF-IR expression. SBC-5 miR-335+, but not SBC-5 miR-29a+, exhibited reduced IGF-IR expression.

The risk for incident cognitive dysfunction after an episode of severe (A) or nonsevere (B) hypoglycemia with and without accounting for the competing.

Three different endocytoses contribute to ATP internalization.

WM volume did not show the expected increase in volume with age in children with type 1 diabetes (●), in contrast with HC subjects (▲) who showed the (expected)

Western blot analysis of explanted human islets from control donors infected in vitro with CBV-1-11 revealed decreased expression of the CAR protein compared.

Receiver operator characteristic (ROC) curve for fasting blood glucose (FBG) predicting posttransplantation diabetes (PTD) using time 0 FBG (a) and screening.

Cumulative distributions of A1C and fasting plasma glucose values for the U.S. population aged ≥12 years without diabetes for each survey cycle: 1999–2000,

Presentation transcript:

Intracellular electrical recordings from islet β-cells exhibiting three types of oscillations. Intracellular electrical recordings from islet β-cells exhibiting three types of oscillations. A: Example of islet with slow oscillations. B: An islet exhibiting fast oscillations. C: An islet with compound oscillations composed of episodes of fast oscillations. Recordings were made using perforated patch and amphotericin B. Ren and Satin, unpublished data. Richard Bertram et al. Diabetes 2018;67:351-359 ©2018 by American Diabetes Association