Dietary baked egg accelerates resolution of egg allergy in children

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Presentation transcript:

Dietary baked egg accelerates resolution of egg allergy in children Stephanie A. Leonard, MD, Hugh A. Sampson, MD, Scott H. Sicherer, MD, Sally Noone, RN, Erin L. Moshier, MS, James Godbold, PhD, Anna Nowak-Węgrzyn, MD Journal of Allergy and Clinical Immunology Volume 130, Issue 2, Pages 473-480.e1 (August 2012) DOI: 10.1016/j.jaci.2012.06.006 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Clinical outcomes of intent-to-treat and comparison groups. BE, Baked egg; RE, regular egg. Journal of Allergy and Clinical Immunology 2012 130, 473-480.e1DOI: (10.1016/j.jaci.2012.06.006) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Development of regular egg tolerance in the intent-to-treat group stratified by initial baked egg challenge: tolerant versus reactive. The log-rank P value comparing time to development of tolerance between the initially baked egg–tolerant versus initially baked egg–reactive groups is .004. Journal of Allergy and Clinical Immunology 2012 130, 473-480.e1DOI: (10.1016/j.jaci.2012.06.006) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Development of regular egg tolerance: per-protocol (PP) versus comparison groups. The log-rank P value comparing survival between the PP versus comparison groups is less than .0001. Journal of Allergy and Clinical Immunology 2012 130, 473-480.e1DOI: (10.1016/j.jaci.2012.06.006) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Criteria for selecting patients for baked and regular egg challenges. Journal of Allergy and Clinical Immunology 2012 130, 473-480.e1DOI: (10.1016/j.jaci.2012.06.006) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Baked-egg muffin recipe developed at the Jaffe Food Allergy Institute. Journal of Allergy and Clinical Immunology 2012 130, 473-480.e1DOI: (10.1016/j.jaci.2012.06.006) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions