Weiyang Lou, Bisha Ding, Weimin Fan Molecular Therapy - Oncolytics

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High Expression of Pseudogene PTTG3P Indicates a Poor Prognosis in Human Breast Cancer Weiyang Lou, Bisha Ding, Weimin Fan Molecular Therapy - Oncolytics Volume 14, Pages 15-26 (September 2019) DOI: 10.1016/j.omto.2019.03.006 Copyright © 2019 The Authors Terms and Conditions

Figure 1 Expression Pattern of PTTG3P in Human Breast Cancer (A) Expression profile of PTTG3P determined by the SAGE Digital Gene Expression Displayer; (B) expression of PTTG3P in different types of cancers by Oncomine analysis of cancer versus normal samples; (C) expression of PTTG3P in breast cancer by Oncomine meta-analysis; and (D) expression of PTTG3P in breast cancer samples compared with matched normal samples. Error bars represent SD. ***p < 0.001. Molecular Therapy - Oncolytics 2019 14, 15-26DOI: (10.1016/j.omto.2019.03.006) Copyright © 2019 The Authors Terms and Conditions

Figure 2 Relationship between Expression of PTTG3P and Various Clinicopathological Parameters of Breast Cancer Determined by the bc-GenExMiner Database (A) Boxplot of PTTG3P expression according to age; (B) boxplot of PTTG3P expression according to nodal status; (C) boxplot of PTTG3P expression according to ER; (D) boxplot of PTTG3P expression according to PR; (E) boxplot of PTTG3P expression according to HER2; (F) boxplot of PTTG3P expression according to basal-like status; (G) boxplot of PTTG3P expression according to triple-negative status; (H) boxplot of PTTG3P expression according to NPI; and (I) boxplot of PTTG3P expression according to SBR. Molecular Therapy - Oncolytics 2019 14, 15-26DOI: (10.1016/j.omto.2019.03.006) Copyright © 2019 The Authors Terms and Conditions

Figure 3 Prognostic Value of PTTG3P in Breast Cancer (A) High expression of PTTG3P indicates a poor RFS of breast cancer (Kaplan-Meier Plotter database); (B) high expression of PTTG3P indicates a poor DMFS of breast cancer (Kaplan-Meier Plotter database); (C and D) high expression of PTTG3P indicates a poor OS of breast cancer (Kaplan-Meier Plotter database); (E) high expression of PTTG3P indicates a poor prognosis of breast cancer (UALCAN database); and (F) high expression of PTTG3P indicates a poor prognosis of breast cancer (OncoLnc database). Molecular Therapy - Oncolytics 2019 14, 15-26DOI: (10.1016/j.omto.2019.03.006) Copyright © 2019 The Authors Terms and Conditions

Figure 4 Construction of PTTG3P-miRNA-mRNA Network and Gene Ontology Functional Annotation and KEGG Pathway Enrichment Analysis for the Co-expressed Genes of PTTG3P (A) The potential pseudogene PTTG3P-miRNA-mRNA regulatory network; (B) expression of miR-129-5p in breast cancer tissues and normal controls determined by starBase v3.0; (C) expression of miR-376c-3p in breast cancer tissues and normal controls determined by starBase v3.0; (D) expression of miR-383-5p in breast cancer tissues and normal controls determined by starBase v3.0; (E) the top 10 enriched biological process (BP) items for the co-expressed genes of PTTG3P; (F) the top 10 enriched cellular component (CC) items for the co-expressed genes of PTTG3P; (G) the top 10 enriched molecular function (MF) items for the co-expressed genes of PTTG3P; and (H) the top 10 enriched KEGG pathway items for the co-expressed genes of PTTG3P. Molecular Therapy - Oncolytics 2019 14, 15-26DOI: (10.1016/j.omto.2019.03.006) Copyright © 2019 The Authors Terms and Conditions

Figure 5 Expression Correlation of PTTG3 with Parental Genes Analyzed by Oncomine, bc-GenExMiner, cBioPortal, and UALCAN Databases (A and B) PTTG3P co-expression of genes analyzed using Oncomine database; (C–E) expression relationship between PTTG3P and PTTG1/PTTG2 in breast cancer analyzed using bc-GenExMiner database; (F and G) expression correlation between PTTG3P and PTTG1/PTTG2 in breast cancer analyzed using cBioPortal database; and (H) expression correlation between PTTG3P and -1 in breast cancer analyzed using the UALCAN database. Molecular Therapy - Oncolytics 2019 14, 15-26DOI: (10.1016/j.omto.2019.03.006) Copyright © 2019 The Authors Terms and Conditions

Figure 6 Expression of PTTG1/PTTG2 and Correlation between PTTG3P Expression and PTTG1/PTTG2 Expression in Clinical Breast Cancer Samples (A) The level of PTTG1 was detected in 16 breast cancer tissues and paired non-tumor tissues by qRT-PCR; (B) the level of PTTG2 was detected in 16 breast cancer tissues and paired non-tumor tissues by qRT-PCR; (C) the correlation of PTTG3P with PTTG1 in the 32 clinical samples; (D) the correlation of PTTG3P with PTTG2 in the 32 clinical samples. Error bars represent SD. **p < 0.01; ns represents no significance. Molecular Therapy - Oncolytics 2019 14, 15-26DOI: (10.1016/j.omto.2019.03.006) Copyright © 2019 The Authors Terms and Conditions

Figure 7 The Visual Flow-Process Diagram of This Study Molecular Therapy - Oncolytics 2019 14, 15-26DOI: (10.1016/j.omto.2019.03.006) Copyright © 2019 The Authors Terms and Conditions