Antirelapse effect of pretransplant exposure to rabbit antithymocyte globulin by Rosy Dabas, Kareem Jamani, Shahbal B. Kangarloo, Poonam Dharmani-Khan, Tyler S. Williamson, Samar Ousia, Caylib Durand, Don Morris, Douglas Mahoney, Lynn Savoie, Ahsan Chaudhry, Victor H. Jimenez-Zepeda, Faisal M. Khan, Andrew Daly, and Jan Storek BloodAdv Volume 3(9):1394-1405 May 14, 2019 © 2019 by The American Society of Hematology

Rosy Dabas et al. Blood Adv 2019;3:1394-1405 © 2019 by The American Society of Hematology

CIR in patients with low (below median) vs high pre-HCT AUC of ATG capable of binding to CD33+ cells (top) or MNCs (bottom). CIR in patients with low (below median) vs high pre-HCT AUC of ATG capable of binding to CD33+cells (top) or MNCs (bottom). Rosy Dabas et al. Blood Adv 2019;3:1394-1405 © 2019 by The American Society of Hematology

CIR in patients with low (below median) vs high post-HCT AUC of ATG capable of binding to lymphocytes. CIR in patients with low (below median) vs high post-HCT AUC of ATG capable of binding to lymphocytes. Rosy Dabas et al. Blood Adv 2019;3:1394-1405 © 2019 by The American Society of Hematology

CI of aGVHD (grade 2-4) in patients with low (below median) vs high post-HCT AUC of ATG capable of binding to lymphocytes, T cells, CD4 T cells, or MNCs. CI of aGVHD (grade 2-4) in patients with low (below median) vs high post-HCT AUC of ATG capable of binding to lymphocytes, T cells, CD4 T cells, or MNCs. Rosy Dabas et al. Blood Adv 2019;3:1394-1405 © 2019 by The American Society of Hematology

CI of cGVHD (moderate to severe) in patients with low (below median) vs high post-HCT AUC of ATG capable of binding to MNCs, lymphocytes, or CD33 cells. CI of cGVHD (moderate to severe) in patients with low (below median) vs high post-HCT AUC of ATG capable of binding to MNCs, lymphocytes, or CD33 cells. Rosy Dabas et al. Blood Adv 2019;3:1394-1405 © 2019 by The American Society of Hematology

Scatter plots of pre- (triangle) or post-AUC (circle) of MNC-binding ATG vs the day of neutrophil (top) or platelet (bottom) engraftment. Scatter plots of pre- (triangle) or post-AUC (circle) of MNC-binding ATG vs the day of neutrophil (top) or platelet (bottom) engraftment. The correlation between pre-AUC and neutrophil engraftment (P = .005) was significant, and the correlation between pre-AUC and platelet engraftment (P = .055) was near significant. There was no significant correlation between post-AUC and neutrophil or platelet engraftment. Rosy Dabas et al. Blood Adv 2019;3:1394-1405 © 2019 by The American Society of Hematology

RFS, cGRFS, and OS in patients with low (below median) vs high pre-HCT AUC of MNC-binding ATG. Rosy Dabas et al. Blood Adv 2019;3:1394-1405 © 2019 by The American Society of Hematology

Summary of the effects of pre- and post-HCT ATG AUCs on clinical outcomes. Rosy Dabas et al. Blood Adv 2019;3:1394-1405 © 2019 by The American Society of Hematology