Loss of Phb2 in β-cells induces development of diabetes over a 3-week period in β-Phb2−/− mice. Loss of Phb2 in β-cells induces development of diabetes.

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Loss of Phb2 in β-cells induces development of diabetes over a 3-week period in β-Phb2−/− mice. Loss of Phb2 in β-cells induces development of diabetes over a 3-week period in β-Phb2−/− mice. A–C: Glucose tolerance test (2 g/kg) in 6 h–fasted β-Phb2−/− (□) and littermate Phb2lox/lox (●) mice. Three-week-old β-Phb2−/− (n = 6) and Phb2fl/fl (n = 4) mice (A), 4-week-old β-Phb2−/− (n = 7) and Phb2fl/fl (n = 6) (B), and 6-week-old β-Phb2−/− (n = 7) and Phb2fl/fl (n = 7) (C) mice. D and E: In addition to blood glucose, plasma insulin levels were determined before and 15 min after glucose injection. β-Phb2−/− (white bars) and littermate Phb2fl/fl (black bars) mice. At 4 weeks of age, β-Phb2−/− (n = 6) and Phb2fl/fl (n = 5) (D) and 6-week-old β-Phb2−/− (n = 3) and Phb2fl/fl (n = 4) animals (E). F: At 10 weeks of age, plasma glucagon levels were determined after 2-h fasting and subsequent 1-h refeeding. β-Phb2−/− (white bars) and littermate Phb2fl/fl (black bars) mice (n = 4/group). Data presented are means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 between the two groups. Sachin Supale et al. Diabetes 2013;62:3488-3499 ©2013 by American Diabetes Association