DBZ treatment can induce virtually complete exfoliation of BE epithelium. DBZ treatment can induce virtually complete exfoliation of BE epithelium. (A,B)

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DBZ treatment can induce virtually complete exfoliation of BE epithelium. DBZ treatment can induce virtually complete exfoliation of BE epithelium. (A,B) Serial sections of a BE epithelial region showing the extensive effects of DBZ treatment. PAS staining (pink) (A) and Ki67 staining (brown) (B) reveal that post-mitotic goblet cells have dissolved into a mucous mass, effectively demonstrating chemical ablation of the metaplastic epithelium by DBZ. Note the apparent absence of effects on the histology of the submucosa. Vivianda Menke et al. Dis. Model. Mech. 2010;3:104-110 ©2010 by The Company of Biologists Limited