Lack of OcaB impairs age-associated B-lymphocyte accumulation in WAT

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Lack of OcaB impairs age-associated B-lymphocyte accumulation in WAT Lack of OcaB impairs age-associated B-lymphocyte accumulation in WAT. A–C: Transitional state of splenic B lymphocytes (A) and accumulation of B cells in iWAT (B) and eWAT (C) in 6-month-old OcaB+/+ and OcaB−/− mice (n = 3/group). Lack of OcaB impairs age-associated B-lymphocyte accumulation in WAT. A–C: Transitional state of splenic B lymphocytes (A) and accumulation of B cells in iWAT (B) and eWAT (C) in 6-month-old OcaB+/+ and OcaB−/− mice (n = 3/group). D: Presence of CD19+ B cells (arrows) in iWAT (magnification ×200) and in one lymph node (magnification ×40) present within iWAT of OcaB+/+ mice. E–H: Blood levels of Igs in 6-month-old OcaB+/+ and OcaB−/− mice (n = 5/group). *P < 0.05; **P < 0.01; ***P < 0.0001. Foll, follicular; KO, knockout (OcaB−/−); MZ, marginal zone; N.D., none detected; NS, not significant; WT, wild type (OcaB+/+ littermates). Sophie Carter et al. Diabetes 2018;67:1285-1296 ©2018 by American Diabetes Association