Summary of the new mechanistic findings of the present study.

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Nadia Dubé *, Alan Cheng * and Michel L. Tremblay * McGill Cancer Centre and Department of Biochemistry, McGill University, 3655 Promenade Sir-William-Osler,

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Summary of the new mechanistic findings of the present study. Summary of the new mechanistic findings of the present study. NO stimulates S-nitrosylation of PTP1B, which decreases its enzymatic activity, thereby limiting the dephosphorylation of tyrosine residues on key insulin signaling proteins (IR, IRS1/2, and Src), which facilitates insulin TET (42). Txnip promotes NO-mediated S-nitrosylation of PTP1B through inhibition of denitrosylases, leading to the inhibition of PTP1B and activation of insulin signaling. pY, tyrosine phosphorylation. Hong Wang et al. Diabetes 2013;62:4030-4042 ©2013 by American Diabetes Association