Lipoprotein lipase is decreased in skeletal muscle of young, lean IR offspring of T2D parents. Lipoprotein lipase is decreased in skeletal muscle of young,

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Lipoprotein lipase is decreased in skeletal muscle of young, lean IR offspring of T2D parents. Lipoprotein lipase is decreased in skeletal muscle of young, lean IR offspring of T2D parents. A: mRNA expression of LPL determined by RT-qPCR using TaqMan probe in control subjects (n = 7) and IR offspring (n = 13). B: Protein expression of LPL measured by Western blotting in control subjects (n = 7) and IR offspring (n = 9). Results represent mean ± SEM. *P < 0.05 vs. age/weight/BMI–matched healthy control subjects. C: Relationship between mitochondrial density measured by electron microscopy and LPL protein expression in skeletal muscle. Katsutaro Morino et al. Diabetes 2012;61:877-887 ©2012 by American Diabetes Association