Reduction of PGC-1α isoforms, SDHA, and Tomm20 in PD

Slides:



Advertisements
Similar presentations
DH E2 infusion significantly increased phosphorylation of the p42 isoform of ERK (A) and of Akt (B) in the DH of OVX females, but not sham GDX males. DH.
Advertisements

Phosphorylation of a tyrosine residue in mGluR1a-CT1 by Fyn.
Surface renderings of the brain activation showing significant activation in the general mixed design ANOVA for the interaction between all three factors,
MN-enriched miRNAs are depleted temporally in ALS rodent model and human patient spinal cord. MN-enriched miRNAs are depleted temporally in ALS rodent.
Active avoidance is impaired in aged mice in both multimodal and visual versions of the task. Active avoidance is impaired in aged mice in both multimodal.
Quantitative RT-PCR results of relative gene expression normalized to wild-type (WT) expression levels for the LjMYB14 transgene (A) and genes specific.
A–E, Active avoidance (A–D) and optokinetic testing (E) in an independent cohort. A–E, Active avoidance (A–D) and optokinetic testing (E) in an independent.
Marker genes are selected for mouse brain cell types and used to estimate cell type profiles. Marker genes are selected for mouse brain cell types and.
Antibody specificity ascertained by 2D-PAGE Western immunoblotting (IEF) of total cellular protein extracts from the RT4 human bladder cancer cell line.
The effect of ETC duration and temperature on imaging depth.
Neuronal ATM level is reduced in mouse models of AD
Immunoblots of PLCβ isoforms in wild-type and PLCβ2/β3-null platelets.
Changes in WM diffusion parameters with increasing age along the length of HG from medial (primary) to lateral (nonprimary). Changes in WM diffusion parameters.
Sequences of two isoforms of Arhgap39/Porf-2 protein in mouse.
Immunohistochemistry of human DLB brains.
Synaptoneurosome enrichment from mouse cortices.
Nrf2−/− mice had higher TGF-β1 transcription and FN expression.
Adult conditional gene deletion of PGC-1α.
Correlation of EEG- and behavioral-based estimates of pairwise face similarity. Correlation of EEG- and behavioral-based estimates of pairwise face similarity.
CK2 phosphorylates mammalian FMRP S499.
Altered luminal pH of the Golgi apparatus in GPHR deficient primary cultured neurons. Altered luminal pH of the Golgi apparatus in GPHR deficient primary.
The adult female mouse ARC and VMH generate newborn neurons that respond to estrogens and leptin. The adult female mouse ARC and VMH generate newborn neurons.
Activation of glial cells.
Results of CFC training and testing.
APT1 palmitoylation and localization.
Western blot analysis of α-Syn-BAC-Tg/GBA-hetero-KO mice at multiple time points. Western blot analysis of α-Syn-BAC-Tg/GBA-hetero-KO mice at multiple.
Increased proIGF-II and decreased IGF-IIR in BTBR compared with B6 mice. Increased proIGF-II and decreased IGF-IIR in BTBR compared with B6 mice. Western.
PGC-1α isoforms. PGC-1α isoforms. A, The illustration of PGC-1α new alternative exons and known exons in RefSeq/Ensembl/UCSC genome references. Human ESTs.
Targeted disruption of the mouse Atp1a2.
Expression profiles of 87 miRNAs expressed in SC
IOP is not affected by microfibril deficiency.
Csmd2 mRNA is expressed in the mouse forebrain.
Chronological changes of pSer46-MARCKS in human α-Syn-BAC-Tg/GBA-hetero-KO mice. pSer46-MARCKS and pSer129-α-Syn were costained in human normal α-Syn-BAC-Tg/glucocerebrosidase.
(A,B) Immunofluorescence of Cx43 (red) and smooth muscle actin (green) in cultured myometrial cells from untreated (A) and tamoxifen-treated (B) Cx43fl/fl:SM-CreERT2.
Synapse composition is unaltered in SynDIG1-deficient synapses.
Aβ-mediated Ras-MAPK signaling and Cyclin D1 expression in B103 cells are dependent on APP expression and can be reversed with MEK or Ras inhibition. Aβ-mediated.
Gene deletion of PGC-1α leads to the loss of dopamine neurons in the SNpc. Gene deletion of PGC-1α leads to the loss of dopamine neurons in the SNpc. A,
Short-term synaptic depression in SCN neurons during stimulus train application. Short-term synaptic depression in SCN neurons during stimulus train application.
Nicotine and amphetamine modify burst and pause activity.
Distribution of examined mRNAs across CeA subcompartments.
GFP is expressed selectively in NPY neurons.
Dissection and clearing of brain subregions.
Using CLARITY to clear and image other organs.
Oligomeric Aβ42 treatment induces expression of Ras and Cyclin D1 and activation of ERK in primary rat cortical neurons. Oligomeric Aβ42 treatment induces.
The P450scc construct increases functional P450scc expression resulting in elevated pregnenolone levels. The P450scc construct increases functional P450scc.
An ERK-signaling process underlies HFS-induced LTP at TA-CA1 synapses.
Leptin-induced LTP involves a PI 3-kinase-dependent process.
Activation of Erk1/2 in cortical neurons of mouse PD/DLB model and human DLB patient. Activation of Erk1/2 in cortical neurons of mouse PD/DLB model and.
Developmental changes in Scn1a expression and susceptibility to hyperthermia-induced seizures. Developmental changes in Scn1a expression and susceptibility.
A, B, Startle magnitude and PPI after treatment with CNO
Β-Catenin regulation of AChR clustering requires interaction with α-catenin. β-Catenin regulation of AChR clustering requires interaction with α-catenin.
Aggregation and toxicity of α-synuclein in HEK293T cells.
Estradiol and diet interact to regulate the number of newborn neurons that express ERα in the ARC and VMH of the adult female mouse. Estradiol and diet.
HFD increased the number of ERα-expressing cells.
Cue-evoked dopamine release dynamics in the NAc shell and core.
Variation in dUTPase expression in cell lines.
Changes in levels of transcripts encoding inflammatory cytokines and GFAP. The amounts of the PCR cDNA products were obtained from phosphorimager readings.
Effects of follicular depletion induced by VCD and chronic 17β-estradiol (E) administration on the relative mRNA expression of PR (left panel) and ERβ.
Power spectra of EMG during the pre- and post-feedback sessions.
E-stimulation of the olfactory nerve evokes PGC inhibitory responses in distant glomeruli. E-stimulation of the olfactory nerve evokes PGC inhibitory responses.
Firing rate during consummatory behavior at the early training time point. Firing rate during consummatory behavior at the early training time point. Cells.
Grand-averaged ERPs across (A) left hemisphere electrodes (P5, P7, P9, PO3, PO7, and O1) and (B) right hemisphere electrodes (P6, P8, P10, PO4, PO8, and.
Time-dependent changes in caspase-3 during reperfusion after 2 hr middle cerebral artery occlusion. Time-dependent changes in caspase-3 during reperfusion.
Effects of CNO on spontaneous locomotion and amphetamine-induced hyperlocomotion. Effects of CNO on spontaneous locomotion and amphetamine-induced hyperlocomotion.
A, The ratio of currents elicited by an EC50 concentration of ACh and 100 µm menthol over the current elicited by ACh alone. A, The ratio of currents elicited.
Simvastatin does not correct AGS in the Fmr1-/y mouse.
Visual deprivation in adults reverses two molecular correlates of cortical maturation. Visual deprivation in adults reverses two molecular correlates of.
CA1 neuronal loss and recovery following forebrain ischemia.
Expression of HIF-1α and β-catenin in hypoxic HCC cell lines and HAL-treated xenografts. Expression of HIF-1α and β-catenin in hypoxic HCC cell lines and.
Expression of Rapgef2 and Rapgef6 in the E13.5 and E15.5 brains.
Presentation transcript:

Reduction of PGC-1α isoforms, SDHA, and Tomm20 in PD Reduction of PGC-1α isoforms, SDHA, and Tomm20 in PD. A, Immunoblots of PGC-1α, SDHA, Tomm20, and β-actin in SN of PD mouse compared with an age-matched control. Reduction of PGC-1α isoforms, SDHA, and Tomm20 in PD. A, Immunoblots of PGC-1α, SDHA, Tomm20, and β-actin in SN of PD mouse compared with an age-matched control. B, Quantitation of the immunoblots in A normalized to β-actin: Control, n = 4; PD mouse, n = 3. *p < 0.05, **p < 0.005. Haisong Jiang et al. eneuro 2016;3:ENEURO.0183-16.2016 ©2016 by Society for Neuroscience