Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers† B.A. Chizh, M.

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Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers† B.A. Chizh, M. Göhring, A. Tröster, G.K. Quartey, M. Schmelz, W. Koppert British Journal of Anaesthesia Volume 98, Issue 2, Pages 246-254 (February 2007) DOI: 10.1093/bja/ael344 Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 1 Enrolment, treatment allocation, and analysis groups. British Journal of Anaesthesia 2007 98, 246-254DOI: (10.1093/bja/ael344) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 2 The effects of oral pregabalin, aprepitant, and placebo on hyperalgesia, allodynia, and pain evoked by electrical stimulation of the skin. The time-course of the area of punctate mechanical hyperalgesia (a), dynamic touch allodynia (b) and ongoing pain intensity (c) for the three treatment groups is plotted as mean (se) over 20–100 min from the onset of stimulation. British Journal of Anaesthesia 2007 98, 246-254DOI: (10.1093/bja/ael344) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 3 The effects of orally administered pregabalin (PGB), aprepitant (NK1), and placebo (PBO) in combinations with i.v. parecoxib (COX) on punctate mechanical hyperalgesia, dynamic touch allodynia, and ongoing pain evoked by electrical stimulation of the skin. The time-course of the area of punctate mechanical hyperalgesia (a), dynamic touch allodynia (b), and ongoing pain intensity (c) for the three treatment groups is plotted as mean (se) over 120–180 min (a, b) or 105–180 min (c) from the onset of stimulation. Parecoxib was administered between 105 and 115 min. British Journal of Anaesthesia 2007 98, 246-254DOI: (10.1093/bja/ael344) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions