A methacholine challenge dose-response study for development of a pharmacodynamic bioequivalence methodology for albuterol metered-dose inhalers Peter.

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A methacholine challenge dose-response study for development of a pharmacodynamic bioequivalence methodology for albuterol metered-dose inhalers Peter S. Creticos, MDa, Wallace P. Adams, PhDb, Brent G. Petty, MDc, Lionel D. Lewis, MBBCh, MDc, Gur Jai Pal Singh, PhDd, Arouna P. Khattignavong, MDa, Justina A. Molzon, MS, JDe, Marilyn N. Martinez, PhDd, Paul S. Lietman, MD, PhDc, Roger L. Williams, MDb Journal of Allergy and Clinical Immunology Volume 110, Issue 5, Pages 713-720 (November 2002) DOI: 10.1067/mai.2002.129036 Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 1 Posterior Bayesian fitting of PD20 as a function of dose for the 15 study subjects. Abscissa scaling is constant for all plots. Ordinate scaling varies with the observed maximal response of individual subjects. The plots reveal dose-response data with low variability (eg, subject 2) and high variability (eg, subject 13). Journal of Allergy and Clinical Immunology 2002 110, 713-720DOI: (10.1067/mai.2002.129036) Copyright © 2002 Mosby, Inc. Terms and Conditions