Anti-DNA Abs were not affected by the deletion of GCs in pristane-induced lupus model. Anti-DNA Abs were not affected by the deletion of GCs in pristane-induced.

Slides:

Advertisements

Similar presentations

Figure 4. Reduced Ab production in Egr1-/- mice

Advertisements

Shigella-specific serum IgG and IgA endpoint titers in guinea pigs immunized intranasally with S. flexneri 2a InvaplexNAT or InvaplexAR. Shigella-specific.

Anti-CD40 and CpG induce activation of T cells in draining lymph nodes

Serum IgG (A–D) and IgA (E–H) titer from BALB/c mice (n = 5/group) at day 0 or following COBRA P1 virus i.n., i.p., or i.m. prime at day 21 or following.

Blocking antibodies induced by immunization with a hypoallergenic parvalbumin mutant reduce allergic symptoms in a mouse model of fish allergy Raphaela.

by Clemens B. Caspar, Shoshana Levy, and Ronald Levy

Volume 37, Issue 6, Pages (December 2012)

Tumor Necrosis Factor Receptor-Associated Factor 3 Is a Critical Regulator of B Cell Homeostasis in Secondary Lymphoid Organs Ping Xie, Laura L. Stunz,

Hypersensitivity and Loss of Disease Site Targeting Caused by Antibody Responses to PEGylated Liposomes Adam Judge, Kevin McClintock, Janet R. Phelps,

Volume 30, Issue 3, Pages (March 2009)

Volume 28, Issue 2, Pages (February 2008)

Breadth of binding and HAI activity of serum Ab from i. n. + i. p

In vivo reconstitution of AP activity in MASP-1/3−/− mice with rMASP-3

Loss of vimentin in B cells impairs antibody response in vivo.

Fluorescence-stained images and respective bright-field images of mouse spleen tissue sections area investigated using Raman spectroscopy. Fluorescence-stained.

HA-specific Abs in serum 14 d after a single vaccination with the various targeted DNA vaccines. HA-specific Abs in serum 14 d after a single vaccination.

A single DNA vaccination of C57BL/6 mice induced Ab responses of IgG1 and/or IgG2c subclass. A single DNA vaccination of C57BL/6 mice induced Ab responses.

Serum IgG subclass representation from BALB/c mice (n = 5/group) following COBRA P1 virus i.n., i.p., or i.m. prime followed by i.p. or i.m. boost. Serum.

Virus-specific serum antibody response of BALB/c mice to DNA prime followed by VRP boost. Virus-specific serum antibody response of BALB/c mice to DNA.

Colonization with N. musculi results in Ab production.

Enhanced proliferation and cytokine production in DGKζ and Cbl-b deficient mice. Enhanced proliferation and cytokine production in DGKζ and Cbl-b deficient.

B-1a and B-1b Cells Exhibit Distinct Developmental Requirements and Have Unique Functional Roles in Innate and Adaptive Immunity to S. pneumoniae Karen.

Virus-specific serum antibody response of BALB/c mice to DNA prime followed by VRP boost. Virus-specific serum antibody response of BALB/c mice to DNA.

Figure 2 Correlation between total IgG levels and anti-AQP4 IgG titer

CXCR5+/+ TFH cells are dispensable for maintenance of the LCMV-specific antibody response. CXCR5+/+ TFH cells are dispensable for maintenance of the LCMV-specific.

GM-CSF–producing γδT cells are involved in the development of EAM

IL-21 is involved in the pathogenesis of EAM

STAT3 regulates IgE class switching in a Th2-type response.

CD160−/− mice have impaired clearance of oral L

CD4 T cells are responsible for the intensified joint pathology at 6 d postinfection. CD4 T cells are responsible for the intensified joint pathology at.

Molecular Therapy - Nucleic Acids

STAT3 regulates GC and plasma cell IgE class switching in B cells.

LP-BM5 retroviral infection increased Ab production.

IFN-γ induces TNF family ligand protein expression in vitro and in vivo. IFN-γ induces TNF family ligand protein expression in vitro and in vivo. (A and.

Volume 119, Issue 3, Pages (September 2000)

Longevity of mucosal and systemic antibody responses induced by pulmonary vaccination. Longevity of mucosal and systemic antibody responses induced by.

Adaptive immune responses and NK activity.

Volume 60, Issue 6, Pages (December 2001)

Deficiency of TLR9 does not affect autoantibody levels but shifts autoantibody specificity. Deficiency of TLR9 does not affect autoantibody levels but.

IL-12 affects Dermatophagoides farinae–induced IL-4 production by T cells from pediatric patients with mite-sensitive asthma Takeshi Noma, MD, PhD, Izumi.

Volume 38, Issue 3, Pages (March 2013)

Hypersensitivity and Loss of Disease Site Targeting Caused by Antibody Responses to PEGylated Liposomes Adam Judge, Kevin McClintock, Janet R. Phelps,

Blimp-1 expression is enhanced in both si-tolerant T cells and CD3/CD155-ligated T cells. Blimp-1 expression is enhanced in both si-tolerant T cells and.

IL-27 contributes to IR expression by lung T cells during toxoplasmosis. IL-27 contributes to IR expression by lung T cells during toxoplasmosis. (A) Il27p28-GFP.

Carmelo Carmona-Rivera et al. Sci. Immunol. 2018;3:eaar3701

Experimental design for serological analyses.

NKTfh cell–driven class switch against polysaccharide Ag is IL-21-influenced. NKTfh cell–driven class switch against polysaccharide Ag is IL-21-influenced.

Receiver operating curve of soluble C3, C4, antibodies to double-stranded DNA (anti-dsDNA) compared with complement C4d levels on erythrocytes (EC4d) and.

Pulmonary vaccination induces a long-term immune memory response to antigen challenge. Pulmonary vaccination induces a long-term immune memory response.

SYK activity is required for anti-IgM–induced DNA synthesis.

Effect of dose level on the anti-keyhole limpet haemocyanin (KLH) IgG response in the multiple-ascending dose (MAD) study. Effect of dose level on the.

OVA-specific and InvaplexNAT-specific serum IgG endpoint titers in mice after intranasal immunization with OVA alone or OVA combined with InvaplexAR, InvaplexNAT,

Removal of both B-1–mediated anti-PC natural IgM and B-2–mediated anti-PEG IgM responses abrogates ABC in mice. Removal of both B-1–mediated anti-PC natural.

Increased autoantibodies in Bcl6FC mice.

Loss of Tfh and GC B cells in 2KO-Bcl6TC mice.

Increased anti-DNA Abs in 2KO-Bcl6TC mice.

Increased autoantibodies in 2KO-Bcl6TC mice.

BMS blocks functional responses in primary immune cells driven by IFNα

Antibody titers against surface antigens of B

Vaginal CD11c+ DCs from IL-17A−/− mice are impaired in potentiating Th17 responses because of diminished IL-1β production. Vaginal CD11c+ DCs from IL-17A−/−

Scattergrams showing IgG- and IgA-specific OD490 values measured with the Campylobacter-specific P18/P39 ELISA in sera from healthy controls and from GBS.

Fig. 6 Multivalent DNA vaccine and protein antigen delivery by T4-AAV nanoparticles. Multivalent DNA vaccine and protein antigen delivery by T4-AAV nanoparticles.

Both the MMP9 and MMP2 systems are activated by anti-Aβ antibodies, IVIg, and mouse IgG. Both the MMP9 and MMP2 systems are activated by anti-Aβ antibodies,

Antibody titers against surface antigens of M

Characterization of mutant flagellin proteins.

p110δ activity is important for autoantibody responses.

E2 induces IL-17–producing γδ+ T cells in the FGT

In the absence of TLR5 and inflammasome recognition, FliC’s D2/D3 domains are essential for secondary IgG1 and IgG2c anti-flagellin responses. In the absence.

Fig. 3 Evaluation of PTMAO immunogenicity.

CCR6 is dispensable for expansion of innate TCRαβ+ cells in oral candidiasis. CCR6 is dispensable for expansion of innate TCRαβ+ cells in oral candidiasis.

Presentation transcript:

Anti-DNA Abs were not affected by the deletion of GCs in pristane-induced lupus model. Anti-DNA Abs were not affected by the deletion of GCs in pristane-induced lupus model. Four months after a single 0.5-ml Pristane i.p. injection, serum samples were collected from control WT and Bcl6TC mice for anti-dsDNA Ab detection by ELISA. (A) Anti-dsDNA IgG and (B) anti-dsDNA IgA titers are shown. The x-axis labels are dilution factors. Data shown as mean ± SEM, n = 5. Data are pooled from two independent experiments. Markus M. Xie et al. ImmunoHorizons 2019;3:306-316 Copyright © 2019 The Authors