Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial  Camarasa M.A. , Ollé.

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Presentation transcript:

Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial  Camarasa M.A. , Ollé G. , Serra-Prat M. , Martín A. , Sánchez M. , Ricós P. , Pérez A. , Opisso L.   British Journal of Anaesthesia  Volume 96, Issue 5, Pages 576-582 (May 2006) DOI: 10.1093/bja/ael057 Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 1 Algorithm used to guarantee masking of study treatment agents. TXA, tranexamic acid; EACA, epsilon-aminocaproic acid; CONT, control group. British Journal of Anaesthesia 2006 96, 576-582DOI: (10.1093/bja/ael057) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 2 Formulae used to calculate total blood loss. TBL, total blood loss; TRCL, total red cell loss; Hi, haematocrit the night before surgery; Hf, haematocrit fifth day after surgery; ARCL, accepted red cell loss; Vth, estimated volaemia (ml); VTRC, volume of transfused red blood cells. British Journal of Anaesthesia 2006 96, 576-582DOI: (10.1093/bja/ael057) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 3 Flow chart of patient progression through trial phases. British Journal of Anaesthesia 2006 96, 576-582DOI: (10.1093/bja/ael057) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 4 Reduction of haemoglobin levels (g dl−1) between preoperative visit and fifth day after surgery. *P<0.05 between the TXA and EACA groups with respect to the CONT group. British Journal of Anaesthesia 2006 96, 576-582DOI: (10.1093/bja/ael057) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

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