Vascular Effects of Cyclosporin A and Acute Rejection in Canine Heart Transplantation Denis Bouchard, MD, Marc-Antoine Despatis, MD, Josie Buluran, BSc,

Slides:

Advertisements

Similar presentations

Urokinase treatment preserves endothelial and smooth muscle function in experimental acute arterial thrombosis David Whitley, MD, Peter Gloviczki, MD,

Advertisements

Bing-Yen Wang, MD, Hsiao-Huang Chang, MD, PhD, I

Increased incidence of acute ascending aortic dissection with off-pump aortocoronary bypass surgery? Olivier Chavanon, MD, Michel Carrier, MD, Raymond.

Therapeutic Effect of Midkine on Cardiac Remodeling in Infarcted Rat Hearts Shinya Fukui, MD, Satoru Kitagawa-Sakakida, MD, PhD, Sin Kawamata, MD, PhD,

Association of CD14+ monocyte-derived progenitor cells with cardiac allograft vasculopathy Mohamed Salama, MD, PhD, Olena Andrukhova, PhD, Susanne Roedler,

Neutrophil Adherence to Activated Saphenous Vein and Mammary Endothelium After Graft Preparation Axel Schlitt, MD, Diethard Pruefer, MD, Ute Buerke,

Cardiomyocyte Transplantation Improves Heart Function

Hypercholesterolemia Impairs the Myocardial Angiogenic Response in a Swine Model of Chronic Ischemia: Role of Endostatin and Oxidative Stress Munir Boodhwani,

Dose responsive suppression of myointimal hyperplasia by dexamethasone

Rodrigo A. S. Sardenberg, MD, Clovis Pinto, MD, Cynthia A

Endothelium-Dependent Vasoconstriction in Isolated Vessel Grafts: A Novel Mechanism of Vasospasm? Markus Hoenicka, PhD, Andreas Keyser, MD, Leopold Rupprecht,

Allogeneic Mesenchymal Precursor Cell Therapy to Limit Remodeling After Myocardial Infarction: The Effect of Cell Dosage Hirotsugu Hamamoto, MD, Joseph.

Bing-Yen Wang, MD, Hsiao-Huang Chang, MD, PhD, I

Thomas V Bilfinger, MD, George B Stefano, PhD

Total orthotopic heart transplantation for primary cardiac rhabdomyosarcoma: factors influencing long-term survival Daniel Grandmougin, MD, Georges Fayad,

Novel Tissue-Engineered Biodegradable Material for Reconstruction of Vascular Wall Shigemitsu Iwai, MD, Yoshiki Sawa, MD, Satoshi Taketani, MD, Kei Torikai,

Alexander S. Farivar, MD, Anton S. McCourtie, MRCS, Brendan C

Interleukin 18 binding protein (IL18-BP) inhibits neointimal hyperplasia after balloon injury in an atherosclerotic rabbit model Jian-Ming Li, MD, Mohammad.

Mark Wengrovitz, MD. , Lulseged G. Selassie, MD. , Robert R. M

Increased connexin43 expression in human saphenous veins in culture is associated with intimal hyperplasia Sébastien Déglise, MD, David Martin, MS, Hervé.

Constructive Remodeling of CorMatrix Extracellular Matrix After Aortic Root Repair in a 90-Year-Old Woman Frank N. Slachman, MD The Annals of Thoracic.

Calcium-Channel Blockers Preserve Coronary Endothelial Reactivity After Ischemia- Reperfusion François Dagenais, MD, Raymond Cartier, MD, Charleen Hollmann,

Improved Myocardial Perfusion and Thickening After Off-Pump Revascularization: 5- Year Follow-Up Chang Young Kim, MD, Ho Young Hwang, MD, Jin Chul Paeng,

Adriana Luk, MD, Robert J. Cusimano, MD, Jagdish Butany, MBBS, MS

Autologous smooth muscle cell transplantation improved heart function in dilated cardiomyopathy Kyung-Jong Yoo, MD, Ren-Ke Li, MD, PhD, Richard D. Weisel,

Lindsay C.H. John, MD, FRCS The Annals of Thoracic Surgery

Inhibitory effect of photooxidation on intimal and medial thickening of saphenous vein Jyotirmay Chanda , MD, Ryosei Kuribayashi, MD, Ke-Xiang Liu, MD,

Reply The Annals of Thoracic Surgery

Mechanisms of arterial graft failure. II

Snaring of the Target Vessel in Less Invasive Bypass Operations Does Not Cause Endothelial Dysfunction Louis P Perrault, Philippe Menasché, Jean-Pierre.

Surgical Resection of a Giant Coronary Aneurysm

Nodular Lymphoid Hyperplasia of the Lung: A Very Rare Disease Entity

Statin Treatment Equalizes Long-Term Survival Between Patients With Single and Bilateral Internal Thoracic Artery Grafts Michel Carrier, MD, Mariève.

Percutaneous Tissue-Engineered Pulmonary Valved Stent Implantation

Induced Pluripotent Stem Cell Transplantation in the Treatment of Porcine Chronic Myocardial Ischemia Yifu Zhou, MD, Suna Wang, MD, Zuxi Yu, MD, PhD,

Novel Anastomotic Device for Distal Coronary Anastomosis: Preclinical Results From Swine Off-Pump Coronary Artery Bypass Model Yoshifumi Itoda, MD, PhD,

James D. St. Louis, MD The Annals of Thoracic Surgery

Novel Method of Decellularization of Porcine Valves Using Polyethylene Glycol and Gamma Irradiation Takeyoshi Ota, MD, PhD, Satoshi Taketani, MD, Shigemitsu.

Role of hemodynamic forces in the ex vivo arterialization of human saphenous veins Xavier Berard, MD, PhD, Sébastien Déglise, MD, Florian Alonso, PhD,

Antisense basic fibroblast growth factor gene transfer reduces neointimal thickening after arterial injury Abigail K. Hanna, MD, Jonathan C. Fox, MD,

Giant-cell temporal arteritis in a 17-year-old male

Effects of thrombolysis and venous thrombectomy on valvular competence, thrombogenicity, venous wall morphology, and function Jae-Sung Cho, MD, Eugenio.

The tissue-engineered vascular graft using bone marrow without culture

Thrombolysis for experimental deep venous thrombosis maintains valvular competence and vasoreactivity Jeffrey M. Rhodes, MD, Jae-Sung Cho, MD, Peter.

Carotid plaque instability and ischemic symptoms are linked to immaturity of microvessels within plaques Benjamin J. Dunmore, PhD, Mark J. McCarthy,

Influence of Diabetes Mellitus on Long-Term Survival in Systematic Off-Pump Coronary Artery Bypass Surgery Bertrand Marcheix, MD, Frédéric Vanden Eynden,

Hypoplasia and fibromuscular dysplasia of infrarenal abdominal aorta with downstream aneurysm: Case report and review of the literature Attilio Odero,

Efficacy of Therapeutic Angiogenesis by Intramyocardial Injection of pCK-VEGF165 in Pigs Jae-Sung Choi, MD, PhD, Ki-Bong Kim, MD, PhD, Woong Han, DVM,

Robert A. McCready, M. D. , Margaret A. Price, B. S. , Richard J

Yehuda G. Wolf, MD, Lars M. Rasmussen, MD, Yoav Sherman, MD, Warner P

Bronchopulmonary Carcinoid Tumor Presenting With Polymyositis

Mostafa N. El-Sanadiki, MB, MS, K. Simon Cross, MB, John J

Coronary artery and myocardial inflammatory reaction induced by intracoronary stent Walter J Gomes, MD, PhD, Osvaldo Giannotti-Filho, MD, PhD, Rodrigo.

Proliferation of smooth muscle cells in acute allograft vascular rejection Jun Amano, MDa, Shigeru Ishiyama, MDb, Toshiro Nishikawa, MDb, Hiroyuki Tanaka,

Distal radial artery lesion as a source of digital emboli

Statin in Combination With β-Blocker Therapy Reduces Postoperative Stroke After Coronary Artery Bypass Graft Surgery Denis Bouchard, MD, Michel Carrier,

Matadial Ojha, PhD, Richard L Leask, K

Postoperative Pleural Effusion in Bronchioloalveolar Cancer

Changes in the cooling rate and medium improve the vascular function in cryopreserved porcine femoral arteries Montserrat Rigol, PhD, Magda Heras, MD,

Histopathology of the Longest-Lived Saphenous Vein Graft in a Patient With Kawasaki Disease Satoru Domoto, MD, Kiyoharu Nakano, MD, Kojiro Kodera, MD,

Invited Commentary The Annals of Thoracic Surgery

Hypoplastic Left Heart Syndrome With Anomalous Origin of the Right Coronary Artery Julie Cleuziou, MD, Felix Haas, MD, Christian Schreiber, MD, Hans-Jörg.

Circumflex Coronary Artery From Right Pulmonary Artery in Hypoplastic Left Heart Syndrome Emmanuel Villa, MD, Gianluca Brancaccio, MD, Adriano Carotti,

Short-term dexamethasone treatment inhibits vein graft thickening in hypercholesterolemic ApoE3Leiden transgenic mice Abbey Schepers, MD, Nuno M.M. Pires,

“Transitions” for Cardiothoracic Surgeons Now Listed on the Web:

Endothelial Cell Injury in Cardiovascular Surgery

Kenton J. Zehr, MD, Alok Mathur, MD, Thomas A. Orszulak, MD, Charles J

Fasudil Is a Superior Vasodilator for the Internal Thoracic Artery in Coronary Surgery Go Watanabe, MD, PhD, Yukihiro Noda, MD, PhD, Takeshi Takagi, MD,

Divided Left Atrium (Cor Triatriatum) in the Setting of Common Atrium

Prevention of stenosis after vascular reconstruction: Pharmacologic control of intimal hyperplasia—A review Alexander W. Clowes, MD, Michael A. Reidy,

Presentation transcript:

Vascular Effects of Cyclosporin A and Acute Rejection in Canine Heart Transplantation Denis Bouchard, MD, Marc-Antoine Despatis, MD, Josie Buluran, BSc, Raymond Cartier, MD The Annals of Thoracic Surgery Volume 64, Issue 5, Pages 1325-1330 (November 1997) DOI: 10.1016/S0003-4975(97)00912-0 Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Light photomicrograph (Movat pentachrome) of a cross-section of the circumflex coronary artery from a transplanted heart displaying severe rejection (not treated). The right panel shows intimal hyperplasia with lymphocyte infiltration and preservation of the endothelial cells (black arrow) along with the internal lamina elastica (ILE). The upper left panel illustrates similar features with a disrupted ILE (black arrow) and lymphocyte infiltration of the underlying smooth muscle. The lower left panel depicts grade IV rejection of the myocardium with severe lymphocyte infiltration and myocyte necrosis (M). The Annals of Thoracic Surgery 1997 64, 1325-1330DOI: (10.1016/S0003-4975(97)00912-0) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Immunohistologic staining for von Willebrand factor of a coronary artery segment from an acutely rejected heart showing morphologically preserved endothelial cells (upper panel: low magnification; lower panel: high magnification). The Annals of Thoracic Surgery 1997 64, 1325-1330DOI: (10.1016/S0003-4975(97)00912-0) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Dose-response curve showing endothelium-dependent relaxation of coronary segments to thrombin. A significantly decreased response is observed among transplanted hearts regardless of the treatment supplied. (NaCyA = native hearts treated with cyclosporine; NA noTx = native hearts without treatment; TR CyA = transplanted hearts treated with cyclosporine; TR noTx = transplanted hearts without treatment.) The Annals of Thoracic Surgery 1997 64, 1325-1330DOI: (10.1016/S0003-4975(97)00912-0) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 (A) Dose-response curve showing endothelium-dependent relaxation of coronary artery segments to 5-hydroxytryptamine (5-HT). A significantly increased response is observed among the transplanted hearts, which was enhanced further by cyclosporine treatment. (B) Dose-response curve showing an endothelium-independent response (rings without endothelium) to 5-HT. Neither the transplant process nor the cyclosporine treatment altered the response. (NA CyA = native hearts treated with cyclosporine; NA noTx = native hearts without treatment; ns = not significant; TR CyA = transplanted hearts treated with cyclosporine; TR noTx = transplanted hearts without treatment.) The Annals of Thoracic Surgery 1997 64, 1325-1330DOI: (10.1016/S0003-4975(97)00912-0) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions