Spinal application of naloxone did not change population responses of superficial and deep WDR neurons to graded intracutaneous electrical stimuli in wild-type.

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Spinal application of naloxone did not change population responses of superficial and deep WDR neurons to graded intracutaneous electrical stimuli in wild-type mice. Spinal application of naloxone did not change population responses of superficial and deep WDR neurons to graded intracutaneous electrical stimuli in wild-type mice. There were no significant differences in population stimulus intensity–response functions of A-fiber-mediated (A) and C-fiber-mediated (B) responses of superficial WDR neurons (depth, <350 μm) to graded electrical stimulation (0.02–5.0 mA, 2 ms) applied in the receptive field between pre-naloxone and post-naloxone conditions (10 mm, 30 μl) in wild-type mice (n = 14; p > 0.05). In a separate group of wild-type mice (n = 12), the population stimulus intensity–response functions of A-fiber-mediated (C) and C-fiber-mediated (D) responses of deep WDR neurons (depth, 350–700 μm) were not significantly different between pre-naloxone and post-naloxone conditions (10 mm, 30 μl; p > 0.05). Saline did not affect stimulus intensity–response functions of A-fiber- and C-fiber-mediated responses in deep WDR neurons (insets in C and D; n = 7; p > 0.05). Data are expressed as mean ± SEM. Yun Guan et al. J. Neurosci. 2006;26:4298-4307 ©2006 by Society for Neuroscience