Effects of ipsilateral sham or dorsal column lesion on the level of NPY-IR in the n. gracilis (A, B), superficial laminas of the ipsilateral dorsal horn.

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Effects of ipsilateral sham or dorsal column lesion on the level of NPY-IR in the n. gracilis (A, B), superficial laminas of the ipsilateral dorsal horn of the spinal cord at the L5 level (C), and the ipsilateral L5DRG (D). Effects of ipsilateral sham or dorsal column lesion on the level of NPY-IR in the n. gracilis (A, B), superficial laminas of the ipsilateral dorsal horn of the spinal cord at the L5 level (C), and the ipsilateral L5DRG (D). Male Sprague Dawley rats received unilateral lesions of the dorsal columns or sham surgery 7 d before L5 and L6 SNL surgery. Spinal nerve injury was performed ipsilateral to the dorsal column lesion or sham. Tissues were harvested 28 d after L5 and L6 SNL. Rats with SNL but with sham lesions of the dorsal columns showed upregulation of NPY-IR in the ipsilateral n. gracilis (A). Lesions of the dorsal columns before SNL blocked this increase in NPY-IR (B). Dorsal column lesions did not block the upregulation of NPY-IR in either the spinal dorsal horn (C) or the L5 DRG (D). Scale bar, 200 μm. Michael H. Ossipov et al. J. Neurosci. 2002;22:9858-9867 ©2002 by Society for Neuroscience