Blockade of the Nogo receptor NgR1 enhances LTP in the rat primary motor cortex. Blockade of the Nogo receptor NgR1 enhances LTP in the rat primary motor.

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Blockade of the Nogo receptor NgR1 enhances LTP in the rat primary motor cortex. Blockade of the Nogo receptor NgR1 enhances LTP in the rat primary motor cortex. Coronal brain slices containing the main forelimb motor cortex were treated with the Nogo-66 antagonist peptide Nep1–40 or a functional Ab against NgR1. Insets show representative FP waveforms taken at the time points indicated by numbers in each figure. Up arrows, LTP induction. A–C, During the last 20 min of saturated LTP, a significant difference between Nep 1–40-treated slices (red; n = 7) and controls (ACSF; gray; n = 9) is observed (p < 0.005; t test). IO strength and paired-pulse analysis reveals no significant differences between Nep 1–40-treated slices and controls. D–F, During the last 20 min of saturated LTP, a significant difference between anti-NgR1-treated (blue; n = 8) and IgG control treated slices (gray; n = 10) is observed (p < 0.005; t test). IO strength reveals no significant difference between anti-NgR1 and control-Ab-treated slices. Paired-pulse analysis reveals significantly higher ratios for anti-NgR1-treated slices compared with IgG controls (p < 0.05). *p < 0.05; **p < 0.01. Ajmal Zemmar et al. J. Neurosci. 2014;34:8685-8698 ©2014 by Society for Neuroscience