Leptin Grows Up and Gets a Neural Network

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Leptin Grows Up and Gets a Neural Network Roger D. Cone, Richard B. Simerly Neuron Volume 71, Issue 1, Pages 4-6 (July 2011) DOI: 10.1016/j.neuron.2011.06.033 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Leptin Regulates the ARC to PVN Circuit via a Distributed Network of Predominantly GABAergic Neurons The diagram shows one example of the hundreds of POMC and NPY/AgRP projections throughout the CNS, and the network of leptin receptor expressing GABAergic neurons controlling this circuit. Major sites of leptin-responsive GABAergic neurons identified in Vong et al. include ARC, LH, and DMH. Note that most of the GABAergic and glutamatergic inputs to the POMC and NPY/AgRP neurons remain undefined. Target neurons in the PVN are highly heterogeneous and are also regulated by a complex network of GABAergic and glutamatergic inputs. Neuron 2011 71, 4-6DOI: (10.1016/j.neuron.2011.06.033) Copyright © 2011 Elsevier Inc. Terms and Conditions