miR-9 regulation of Pax6 expression.

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Presentation transcript:

miR-9 regulation of Pax6 expression. miR-9 regulation of Pax6 expression. A, Immunohistology of Pax6 (green) and Meis2 (red) protein expression in the E15.5 telencephalon. B, RNA in situ hybridization of Meis2 expression, anti-Meis2 or anti-Pax6 staining, and merged views of Meis2 and Pax6 protein expression with DAPI staining in the E15.5 pallium. C, miR-9-2 suppression of luciferase expression from a reporter conjugated to the wild-type and mutant Pax6 and Meis2 3′ UTRs; in mutant miR-9-2 (miR-9-2Mt), the mutation was introduced in the miR-9 seed sequences. D, Quantitative RT-PCR analyses of Pax6 mRNA expression at indicated stages. Scale bars: A, 200 μm; B, 50 μm. Mikihito Shibata et al. J. Neurosci. 2011;31:3407-3422 ©2011 by Society for Neuroscience