COPD:.

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COPD (Chronic Obstructive Pulmonary Disease)

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COPD:

Histological analysis of filtered air- and cigarette smoke-exposed mice. Mice were exposed for 6 mo to either filtered air or cigarette smoke. Lungs were fixed and used for morphological analyses as described in the Materials and Methods. A, Airspace enlargement occurred in cigarette smoke-exposed mice as shown by representative H&E stained slides. Original magnification is at ×200. B, Mucus cell metaplasia developed in cigarette smoke-exposed mice as indicated by PAS-positive cells. Positive cells are indicated by arrows. Original magnification is at ×400. C, Macrophage accumulation occurred in cigarette smoke-exposed mice as indicated by Mac-3 staining. Mac-3 positive cells are indicated by arrows. Original magnification is at ×400.