Volume 59, Issue 4, Pages (April 2001)

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Volume 59, Issue 4, Pages 1544-1550 (April 2001) A novel immunoadsorption device for removing β2-microglobulin from whole blood Guillermo A. Ameer, Eric A. Grovender, Hidde Ploegh, David Ting, William F. Owen, Maria Rupnick, Robert Langer Kidney International Volume 59, Issue 4, Pages 1544-1550 (April 2001) DOI: 10.1046/j.1523-1755.2001.0590041544.x Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 1 Diagram outlining the design of the vortex flow plasmapheretic reactor (VFPR; 6.5 × 15 cm). The total reactor volume was 125 mL, which was distributed among the whole blood, adsorptive plasma, and plasma collection chambers as 50, 70, and 5 mL, respectively. The volume of the plasma tubing was 10 mL. The whole blood path is shown in dark gray, while regions accessible to only plasma are shown in light gray. The settled volume of agarose gel beads was 48 mL. Kidney International 2001 59, 1544-1550DOI: (10.1046/j.1523-1755.2001.0590041544.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 2 Diagram of the circuit used to study the clearance of β2-microglobulin (β2m) from human blood. The overall circulation flow rate was set at 200 mL/min. The plasma pump was calibrated to 50 mL/min, and the rotation rate was set at 1150 r.p.m. The volume of the tubing running from the blood bag to the VFPR was 60 mL, while the return tubing was 5 mL. The blood temperature at the VFPR inlet and outlet was 35°C during the clearance of recombinant human β2m (rβ2m). Kidney International 2001 59, 1544-1550DOI: (10.1046/j.1523-1755.2001.0590041544.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 3 Kinetics of rβ2m clearance from human blood with a BBM.1-loaded VFPR in vitro. Symbols are: (♦) blood bag; (- – -) plasma line. Error bars represent the standard error of the mean (SEM, N = 4). Kidney International 2001 59, 1544-1550DOI: (10.1046/j.1523-1755.2001.0590041544.x) Copyright © 2001 International Society of Nephrology Terms and Conditions