Early-life environmental exposures interact with genetic susceptibility variants in pediatric patients with eosinophilic esophagitis  Elizabeth T. Jensen, MPH, PhD, Jonathan T. Kuhl, BS, Lisa J. Martin, PhD, Carl D. Langefeld, PhD, Evan S. Dellon, MD, MPH, Marc E. Rothenberg, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 141, Issue 2, Pages 632-637.e5 (February 2018) DOI: 10.1016/j.jaci.2017.07.010 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Case-only assessment of gene-environment interaction in patients with EoE. The illustration shows association between exposure and genotype in cases only to assess for gene-environment interaction adjusted for maternal education. *Suggestive associations examined in case-control data assessment of interaction. **Data are too sparse for estimation of association. Journal of Allergy and Clinical Immunology 2018 141, 632-637.e5DOI: (10.1016/j.jaci.2017.07.010) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Case-control analysis interaction plots for early-life factors and susceptibility genotype. Plots denote interaction between selected exposures and genotype variants in the case-control analyses. Interaction models include adjustment for maternal education. G+, Exposed to susceptibility genotype variant; G-, unexposed to susceptibility genotype variant. A, Difference in risk for those breast-fed and not breast-fed among those with the susceptibility genotype variant. B, Increase in risk for NICU admission and those without the susceptibility variant. Journal of Allergy and Clinical Immunology 2018 141, 632-637.e5DOI: (10.1016/j.jaci.2017.07.010) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions