CD4/CD8 double-negative early-stage mycosis fungoides associated with primary cutaneous follicular center lymphoma Jeong Hee Cho-Vega, MD, PhD, Jaime.

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CD4/CD8 double-negative early-stage mycosis fungoides associated with primary cutaneous follicular center lymphoma Jeong Hee Cho-Vega, MD, PhD, Jaime A. Tschen, MD, Francisco Vega, MD, PhD Journal of the American Academy of Dermatology Volume 65, Issue 4, Pages 884-886 (October 2011) DOI: 10.1016/j.jaad.2010.10.026 Copyright © 2010 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 A, MF lesions on the thigh. Multiple erythematous scaly patches with vague annular borders on both anterior thighs. Some of them are covered by hemorrhagic crust due to an irritation. B, Diffuse atypical lymphocytic infiltrate affecting full thickness of the epidermis and the dermoepidermal junction. Mild perivascular atypical lymphocytic infiltrate was also present in upper dermis. Atypical lymphocytes were CD3+ T cells (C), negative for both CD4 (D) and CD8 (E). Few reactive T cells expressed either CD4 or CD8 in the upper dermis. F, Cutaneous follicular center lymphoma on the scalp. An enlarged 2×2 cm nodule on the left posterior scalp. The neoplasm infiltrated the entire dermis (G). Tumor showed follicular growth pattern with predominance of large centroblasts (G, inset). The neoplastic cells were positive for CD20 (H), BCL6 (I); they were negative for BCL2 (J). (Original magnifications: B-E, ×200; G, ×2; G inset, ×400; H-J, ×100.) Journal of the American Academy of Dermatology 2011 65, 884-886DOI: (10.1016/j.jaad.2010.10.026) Copyright © 2010 American Academy of Dermatology, Inc. Terms and Conditions