Antigen Smuggling in Tuberculosis

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Antigen Smuggling in Tuberculosis Denis Hudrisier, Olivier Neyrolles Cell Host & Microbe Volume 15, Issue 6, Pages 657-659 (June 2014) DOI: 10.1016/j.chom.2014.05.018 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 The Role of Antigen Transfer from Infected DCs to Uninfected DCs in the Activation of Antimycobacterial CD4+ T Cells M. tuberculosis is phagocytosed by immature DCs in the lung. Infected DCs mature and migrate to the draining mediastinal lymph node, where they poorly present antigens to CD4+ T cells. In the lymph node, infected DCs secrete unprocessed mycobacterial antigens that are captured, processed, and presented to CD4+ T lymphocytes by resident DCs, which stimulates T cell proliferation. Cell Host & Microbe 2014 15, 657-659DOI: (10.1016/j.chom.2014.05.018) Copyright © 2014 Elsevier Inc. Terms and Conditions