GWAS Meets TCGA to Illuminate Mechanisms of Cancer Predisposition

Slides:

Advertisements

Similar presentations

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E Yumi Kim, Andrew J. Holland, Weijie Lan, Don W. Cleveland.

Advertisements

Waging War on Cancer with the Sword of Immunity Cell Volume 158, Issue 2, (July 2014) DOI: /j.cell Copyright © 2014 Terms and Conditions.

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells Jenny M. Karo, David G. Schatz, Joseph C. Sun Cell Volume.

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity Jenni Durieux, Suzanne Wolff, Andrew Dillin Cell Volume 144, Issue 1, Pages.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

3.3 Å Cryo-EM Structure of a Nonenveloped Virus Reveals a Priming Mechanism for Cell Entry Xing Zhang, Lei Jin, Qin Fang, Wong H. Hui, Z. Hong Zhou Cell.

Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity Michael S. Rooney, Sachet A. Shukla, Catherine J. Wu, Gad Getz,

Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr

Transcriptional Control of Gene Expression by MicroRNAs Basel Khraiwesh, M. Asif Arif, Gotelinde I. Seumel, Stephan Ossowski, Detlef Weigel, Ralf Reski,

Common Sense about Taste: From Mammals to Insects David A. Yarmolinsky, Charles S. Zuker, Nicholas J.P. Ryba Cell Volume 139, Issue 2, Pages (October.

UvrD Helicase Unwinds DNA One Base Pair at a Time by a Two-Part Power Stroke Jae Young Lee, Wei Yang Cell Volume 127, Issue 7, Pages (December.

Nucleation and Transport Organize Microtubules in Metaphase Spindles Jan Brugués, Valeria Nuzzo, Eric Mazur, Daniel J. Needleman Cell Volume 149, Issue.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Xenobiotics Shape the Physiology and Gene Expression of the Active Human Gut Microbiome Corinne Ferrier Maurice, Henry Joseph Haiser, Peter James Turnbaugh.

Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: /j.cell Copyright © 2012 Terms and Conditions Terms and Conditions.

Computational Modeling of Pancreatic Cancer Reveals Kinetics of Metastasis Suggesting Optimum Treatment Strategies Hiroshi Haeno, Mithat Gonen, Meghan.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation Joseph Tcherkezian, Perry A. Brittis, Franziska Thomas,

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia Tim C.P. Somervaille, Michael L. Cleary Cancer Cell.

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.

The Good Fat Cell Volume 147, Issue 7, (December 2011) DOI: /j.cell Copyright © 2011 Terms and Conditions Terms and Conditions.

P120-Catenin Mediates Inflammatory Responses in the Skin Mirna Perez-Moreno, Michael A. Davis, Ellen Wong, H. Amalia Pasolli, Albert B. Reynolds, Elaine.

A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair Julian Stingele, Michael S. Schwarz, Nicolas Bloemeke, Peter G. Wolf, Stefan Jentsch.

A View to a Kill: The Bacterial Type VI Secretion System Brian T. Ho, Tao G. Dong, John J. Mekalanos Cell Host & Microbe Volume 15, Issue 1, Pages 9-21.

Pulsed Forces Timed by a Ratchet-like Mechanism Drive Directed Tissue Movement during Dorsal Closure Jerome Solon, Aynur Kaya-Çopur, Julien Colombelli,

The Search for Antiaging Interventions: From Elixirs to Fasting Regimens Rafael de Cabo, Didac Carmona-Gutierrez, Michel Bernier, Michael N. Hall, Frank.

Systematic Identification of Molecular Subtype-Selective Vulnerabilities in Non-Small- Cell Lung Cancer Hyun Seok Kim, Saurabh Mendiratta, Jiyeon Kim,

Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits Yiming Chen, Yen-Chu Lin, Tzu-Wei Kuo, Zachary A. Knight Cell Volume 160, Issue 5,

Sex-Specific Aging in Flies, Worms, and Missing Great-Granddads

Cancer: Inappropriate Expression of Stem Cell Programs?

Joanna Wang, Chetan Bettegowda The Journal of Molecular Diagnostics

Tumor Evolution: A Problem of Histocompatibility

Cross-Species Oncogenomics in Cancer Gene Identification

DAISY: Picking Synthetic Lethals from Cancer Genomes

Personalized Disease Models on a Chip

Skill Development in Graduate Education

Metabolic Phenotyping in Health and Disease

In This Issue Cell Volume 158, Issue 5, (August 2014)

MicroRNAs and Parallel Stem Cell Lives

Arnaud Chiolero The Lancet Public Health

Wilberto Nieves-Neira, J. Julie Kim, Daniela Matei

The Post-GWAS Era: From Association to Function

Cancer Genomes Evolve by Pulverizing Single Chromosomes

It’s a SMAD/SMAD World Cell

David A. Tuveson, John P. Neoptolemos Cell

Eukaryotic Transcription Activation: Right on Target

Volume 152, Issue 1, (January 2013)

Lung Cancer: A Wily Genetic Opponent

The Many Faces of PPARγ Cell

Personalized Disease Models on a Chip

Volume 130, Issue 6, (September 2007)

Modeling Transcriptome Dynamics in a Complex World

Fishing for Biomarkers with Antigen Mimics

Volume 143, Issue 6, (December 2010)

A FIRE-y PAGE in the Computational Analysis of Cancer Profiles

The Plasticity of Aging: Insights from Long-Lived Mutants

Learning from the Uncontrollable

Hisataka Kobayashi, Peter L. Choyke Kidney International

To Infinium, and Beyond! Cancer Cell

Volume 163, Issue 4, (November 2015)

Volume 163, Issue 2, (October 2015)

An Amazing Turn of Events

Chapter 77 Cervical Cancer: Burden of Disease

Volume 134, Issue 6, (September 2008)

In This Issue Cell Volume 145, Issue 3, (April 2011)

Volume 148, Issue 1, (January 2012)

Targeting Protein Stability with a Small Molecule

Presentation transcript:

GWAS Meets TCGA to Illuminate Mechanisms of Cancer Predisposition Hyun Seok Kim, John D. Minna, Michael A. White Cell Volume 152, Issue 3, Pages 387-389 (January 2013) DOI: 10.1016/j.cell.2013.01.027 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Bridging the Gap between Detection of Cancer Risk Loci and Development of Disease Prevention Strategies High-resolution annotation of molecular correlates in tumor samples can be dovetailed with GWAS to elaborate causal relationships between risk loci and target genes. These target genes serve as both functional and predictive biomarkers for personalized medicine. This, in turn, can lead to testable mechanistic hypotheses and nomination of early detection and prevention strategies. Cell 2013 152, 387-389DOI: (10.1016/j.cell.2013.01.027) Copyright © 2013 Elsevier Inc. Terms and Conditions