Pioglitazone lowers glucose overload but only partially improves cardiac function. Pioglitazone lowers glucose overload but only partially improves cardiac.

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Pioglitazone lowers glucose overload but only partially improves cardiac function. Pioglitazone lowers glucose overload but only partially improves cardiac function. Six-week-old SKO mice were treated with pioglitazone-enriched diet (300 mg/kg) for 8 weeks. Echocardiography Doppler flow analysis was performed: E/A ratio (A), isovolumetric relaxation (B), and deceleration time (C). White bars represents WT mice (n = 8), black bars represent nontreated SKO mice (n = 14), and gray bars represent pioglitazone-treated SKO mice (KO PIO; n = 8). CMR analysis performed in SKO (black bars) and KO PIO (gray bars) mice and compared with previously obtained data from WT mice: EDW (D), EF (E), and EDV (F). Total O-GlcNAcylated protein levels (G), FOXO1 O-GlcNAcylated protein levels (H), and AMPk activation and PLN phosphorylation levels (I) evaluated by Western blot. PSer-PLN, phospho-Ser-PLN. Significant differences between WT and SKO mice are represented as follows: *P < 0.05; **P < 0.01; ***P < 0.001. Significant differences between SKO control and KO PIO were represented as follows: #P < 0.05; ##P < 0.01. Michael Joubert et al. Diabetes 2017;66:1030-1040 ©2017 by American Diabetes Association