Least squares mean changes from baseline (and 95% CIs) at month three for (A) HAQ-DI, (B) FACIT-F and (C) SF-36 physical functioning domain observed in.

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Least squares mean changes from baseline (and 95% CIs) at month three for (A) HAQ-DI, (B) FACIT-F and (C) SF-36 physical functioning domain observed in anti-CCP+/RF+, anti-CCP+/RF-, anti-CCP-/RF+ and anti-CCP-/RF- patients receiving tofacitinib 5 or 10 mg two times a day or placebo. for HAQ-DI and FACIT-F, p≤0.05 with tofacitinib 5 mg two times a day compared with placebo in anti-CCP+/RF+, anti-CCP+/RF- and anti-CCP-/RF+ subgroups and p≤0.05 with tofacitinib 10 mg two times a day compared with placebo across all serotype subgroups. for SF-36 physical functioning domain, p≤0.05 with tofacitinib 5 and 10 mg two times a day compared with placebo across all serotype subgroups. Least squares mean changes from baseline (and 95% CIs) at month three for (A) HAQ-DI, (B) FACIT-F and (C) SF-36 physical functioning domain observed in anti-CCP+/RF+, anti-CCP+/RF-, anti-CCP-/RF+ and anti-CCP-/RF- patients receiving tofacitinib 5 or 10 mg two times a day or placebo. for HAQ-DI and FACIT-F, p≤0.05 with tofacitinib 5 mg two times a day compared with placebo in anti-CCP+/RF+, anti-CCP+/RF- and anti-CCP-/RF+ subgroups and p≤0.05 with tofacitinib 10 mg two times a day compared with placebo across all serotype subgroups. for SF-36 physical functioning domain, p≤0.05 with tofacitinib 5 and 10 mg two times a day compared with placebo across all serotype subgroups. BID, two times a day; CCP, cyclic citrullinated peptide; FACIT-F, Functional Assessment of Chronic Illness Therapy-Fatigue; HAQ-DI, Health Assessment Questionnaire-Disability index; LSM, least squares mean; RF, rheumatoid factor; SF-36, Short Form-36 Health Survey. Paul Bird et al. RMD Open 2019;5:e000742 Copyright © BMJ Publishing Group & EULAR. All rights reserved.