Intrauterine microdialysis reveals cycle-dependent regulation of endometrial insulin-like growth factor binding protein-1 secretion by human chorionic.

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Intrauterine microdialysis reveals cycle-dependent regulation of endometrial insulin-like growth factor binding protein-1 secretion by human chorionic gonadotropin Peter Licht, M.D., Vassili Russu, M.D., Silke Lehmeyer, Johannes Möll, Ernst Siebzehnrübl, M.D., Ludwig Wildt, M.D. Fertility and Sterility Volume 78, Issue 2, Pages 252-258 (August 2002) DOI: 10.1016/S0015-0282(02)03226-0

FIGURE 1 Selective expression of IGFBP-1 in the uterine fluid of the late luteal phase. All women examined before day 10 after the beginning of the LH peak were IGFBP-1 negative. On day 10, all women except one had IFGBP-1 levels of >2 ng/mL. On day 11 and day 12 after the beginning of the LH peak, all women investigated were IGFBP-1 positive. This cycle dependency was statistically significant (P<.0001). Licht. hCG and IGFBP-1. Fertil Steril 2002. Fertility and Sterility 2002 78, 252-258DOI: (10.1016/S0015-0282(02)03226-0)

FIGURE 2 Dynamics of hCG’s effect on intrauterine IGFBP-1 levels in a typical woman. Intrauterine microdialysis was performed 12 days after the beginning of the LH peak. The uterine effluent was collected in fractions of 1 hour each. After 2 hours, hCG infusion (500 IU/h) was started for 5 hours. Immediately after the start of infusion, intrauterine IGFBP-1 levels started to decline. Similar results were obtained in the majority of 45 women treated with hCG. Mean levels of intrauterine IGFBP-1 during hCG infusion were significantly lower as compared with those before the start of infusion (P<.01). Licht. hCG and IGFBP-1. Fertil Steril 2002. Fertility and Sterility 2002 78, 252-258DOI: (10.1016/S0015-0282(02)03226-0)

FIGURE 3 Selective inhibition of intrauterine IGFBP-1 levels by hCG in the late luteal phase of the menstrual cycle. Means ± SEM are depicted for all women investigated in the midluteal phase between day 5 and day 9 (A) or during the late luteal phase at or after day 10 (B) after the beginning of the LH peak. Although there was no significant effect of hCG on IGFBP-1 levels in the first group, hCG provoked a significant decrease in intrauterine IGFBP-1 levels as compared with the case of untreated controls in the late luteal phase (P=.023). Licht. hCG and IGFBP-1. Fertil Steril 2002. Fertility and Sterility 2002 78, 252-258DOI: (10.1016/S0015-0282(02)03226-0)