Macrophage Cytoplasmic Transfer in Melanoma Invasion

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Macrophage Cytoplasmic Transfer in Melanoma Invasion Pakavarin Louphrasitthiphol, Colin R. Goding Developmental Cell Volume 43, Issue 5, Pages 543-544 (December 2017) DOI: 10.1016/j.devcel.2017.11.012 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Donation of Macrophage Cytoplasm Correlates with Melanoma Cell Invasion Top: Injection of melanoma cells into zebrafish larvae hindbrain is accompanied over time by increased TNFα-negative M2 macrophage (Mϕ) infiltration. Bottom: Macrophages expressing Cre recombinase make intimate and prolonged contact with red fluorescent melanoma cells. Cytoplasmic transfer from the macrophages to the melanoma cells leads to donation of Cre recombinase, which confers a red-to-green switch in melanoma cell fluorescence that correlates with increased invasive behavior. Developmental Cell 2017 43, 543-544DOI: (10.1016/j.devcel.2017.11.012) Copyright © 2017 Elsevier Inc. Terms and Conditions