Challenges and Emerging Solutions in Anemia Management Explored

Patient Case

Evaluate for Iron Deficiency

Oral vs IV Iron

Patient Case (cont)

Considering QoL Prior to Initiating ESAs

Guideline Recommendations for Initiating ESA in Adult CKD ND Patients[a]

Factors to Consider When Assessing the Patient

ESA Use in CKD and CVOTs

Evaluating Iron Therapy and ESA Use in Anemia

ESA Resistance or Hyporesponsiveness

HIF-PHIs or HIF Stabilizers

HIF-PHI Mechanism of Action

Erythropoietic Response via HIF

Roxadustat Achieves Target Hb Within or Near Physiologic EPO Cmax Levels

HIF-PH Inhibitors Under Development*

Efficacy in Raising Hemoglobin

Safety of HIF-PHIs

HIF-Stabilizers Safety Concerns

Who Should Be Treated With HIF-PHIs?

Potential Cost Issues with HIF-PHIs

Summary

Abbreviations

Abbreviations (cont)