Cyclic changes in the mammary gland of cynomolgus macaques

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Presentation transcript:

Cyclic changes in the mammary gland of cynomolgus macaques Petra Stute, M.D., Charles E. Wood, D.V.M., Jay R. Kaplan, Ph.D., J. Mark Cline, D.V.M., Ph.D. Fertility and Sterility Volume 82, Pages 1160-1170 (October 2004) DOI: 10.1016/j.fertnstert.2004.04.035 Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Percentages of cells within the mammary gland epithelium labeling positively for the proliferation marker Ki67 via immunohistochemistry. Red = all labeled lobuloalveolar cells; Pink = strongly labeled lobuloaleolar cells; Dark blue = all labeled ductal epithelial cells; Light blue = strongly labeled ductal cells. Staining in lobuloalveolar cells was greater in the follicular phase (*= P<0.05), and staining in ductal cells was greater in luteal phase (**= P<0.05). Fertility and Sterility 2004 82, 1160-1170DOI: (10.1016/j.fertnstert.2004.04.035) Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Percentages of cells within the mammary gland epithelium labeling positively for progesterone receptors via immunohistochemistry. Red = lobuloalveolar epithelial cells; Blue = ductal epithelial cells. Staining in ductal cells was lower in the luteal phase (*= P<0.05). Fertility and Sterility 2004 82, 1160-1170DOI: (10.1016/j.fertnstert.2004.04.035) Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions

FIGURE 3 Percentages of cells within the mammary gland epithelium labeling positively for CPP32 by immunohistochemistry. Red = lobuloalveolar epithelial cells; Blue = ductal epithelial cells. Staining in lobuloalveolar cells was greater in the luteal phase (*= P<0.05). Fertility and Sterility 2004 82, 1160-1170DOI: (10.1016/j.fertnstert.2004.04.035) Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions

FIGURE 4 Percentages of cells within the mammary lobuloalveolar and ductal cells labeling positively for estrogen receptors (ER) alpha and beta via immunohistochemistry. Red = ER-alpha in lobuloalveolar cells; Pink = ER-beta in lobuloaleolar cells; Dark blue = ER-alpha in ductal epithelial cells; Light blue = ER-beta in ductal cells. There were no differences for cycle stage, but ER-beta was always more abundant (P<.05). Fertility and Sterility 2004 82, 1160-1170DOI: (10.1016/j.fertnstert.2004.04.035) Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions

FIGURE 5 Representative photomicrographs of the immunohistochemical stains evaluated. Objective magnification ×20. (A) Ki67. (B) CPP32. (C) Progesterone receptor. (D) Estrogen receptor alpha. (E) Estrogen receptor beta. Fertility and Sterility 2004 82, 1160-1170DOI: (10.1016/j.fertnstert.2004.04.035) Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions