"Attitude is a little thing that can make all the difference." 9/3/2019 Title: Biology 2/9/07 Objectives: To assess learning about some of the aberrations to Mendelian genetics and dihybrid crosses and continue to learn about pedigree analysis Class Topics Hand in Interpreting Information in a Pedigree W.S. before the bell rings please (not 3A) Chapter 8 – Beyond Mendel Sex-linked inheritance Pedigree lab "Attitude is a little thing that can make all the difference." Sir Winston Churchill Tuesday, September 03, 2019 12:57 PM

Class Assignments Read 177-182 2/9/07 9/3/2019 Class Assignments What By When Read 177-182 2/9/07 W.S. Interpreting Information in a Pedigree 2/9/07 Lab – A Human Pedigree 2/9/07 W.S. 8.2 (DR/Color Blind/Gene Spy) 2/13/07 Due this class period Due next class period Due in the future

9/3/2019 Grade Sheet 2A – p. 157 (5 pts.)

Sex-linked inheritance 9/3/2019 Some genes are carried on the X chromosome - Sex-linked genes Fruit flies example White eyed male with red eyed female = all red eyed offspring Crossed two of the F1 offspring and ended up with 3:1 ratio - red to white (all white eyed flies were male!!!) Sex-linked inheritance

Sex-linked inheritance 9/3/2019 Sex-linked inheritance Found mostly in males Males are hemizygous Cannot hide recessive allele Cannot be carriers of trait Females can show trait Must be homozygous recessive Can carry trait (heterozygous) Has nothing to do with hormones Sex-influenced traits

X-linked Traits (Human) 9/3/2019 Hemophilia Queen Victoria (1819-1901), clotting factors Red-Green colorblindness Duchenne Muscular Dystrophy affects children 3-6 years old defective protein causes muscles to weaken X-linked Traits (Human)

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Lab - A Human Pedigree Work in partners (one sheet, two names) 9/3/2019 Lab - A Human Pedigree Work in partners (one sheet, two names) Older answers odd questions Younger answers even questions Turn in when done! Pick up and work on (by yourself) W.S. 8.2 (DR/Color Blind/Gene Spy)

Sex-linked Punnett Squares 9/3/2019 X X x X Y Cross a hemophiliac carrier with a person without hemophilia Sex-linked Punnett Squares X X X Y

Sex-linked Inheritance 9/3/2019 Sex-linked questions What do you know about the parents of a colorblind girl? What do you know about the father of a hemophilia carrier? Sex-linked Inheritance Hemophilia Pedigree Colorblindness