Thomas K. Waddell, MD PhD, Reginald M. Gorczynski, PhD, Kleber N

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Presentation transcript:

Major Histocompatibility Complex Expression and Lung Ischemia-Reperfusion in Rats Thomas K. Waddell, MD PhD, Reginald M. Gorczynski, PhD, Kleber N. DeCampos, MD, G. Alexander Patterson, MD, Arthur S. Slutsky, MD The Annals of Thoracic Surgery Volume 62, Issue 3, Pages 866-872 (August 1996) DOI: 10.1016/S0003-4975(96)00509-7 Copyright © 1996 The Society of Thoracic Surgeons Terms and Conditions

Fig. 1 Survival after ischemia-reperfusion lung injury and the effect of deflation. Survival is decreased due to increased lung injury in animals treated with 4 hours of ischemia and, to a greater degree, in animals treated with 2 hours of ischemia while the lung was atelectatic. The Annals of Thoracic Surgery 1996 62, 866-872DOI: (10.1016/S0003-4975(96)00509-7) Copyright © 1996 The Society of Thoracic Surgeons Terms and Conditions

Fig. 2 Ischemia-reperfusion injury increases pulmonary major histocompatibility complex expression. At 9 days after injury there is a significant increase in binding of radiolabeled anti-class II antibody to the injured left lung compared with the nonischemic right lung (n = 5 in all groups). (*p < 0.01 by analysis of variance compared with normal left lung and also by paired t test compared with matched nonischemic right lungs.) (CPM = counts per minute.) The Annals of Thoracic Surgery 1996 62, 866-872DOI: (10.1016/S0003-4975(96)00509-7) Copyright © 1996 The Society of Thoracic Surgeons Terms and Conditions

Fig. 3 Duration of ischemia increases the degree of major histocompatibility complex expression. Significant increases in binding of radiolabeled anti-class II antibody are seen after 4 hours of ischemia (*p < 0.05), whereas lesser increases are seen after 2 hours of ischemia in the inflated state (n = 5 in all groups). (CPM = counts per minute.) The Annals of Thoracic Surgery 1996 62, 866-872DOI: (10.1016/S0003-4975(96)00509-7) Copyright © 1996 The Society of Thoracic Surgeons Terms and Conditions

Fig. 4 Deflation during ischemia augments increased class II expression. There is significant binding of anti-class II antibody to the left lung after atelectatic injury, which is larger and more significant than after 2 hours of inflated ischemia (n = 5 in all groups). (CPM = counts per minute; *p = 0.085 by analysis of variance compared with normal left lung; **p = 0.015.) The Annals of Thoracic Surgery 1996 62, 866-872DOI: (10.1016/S0003-4975(96)00509-7) Copyright © 1996 The Society of Thoracic Surgeons Terms and Conditions

Fig. 5 Allostimulation acts in combination with ischemia to increase class II major histocompatibility complex expression. Binding of radiolabeled anti-class II antibody is much greater after ischemia with concurrent allostimulation with Lewis mononuclear cells than after either ischemia alone or sham ischemia and allostimulation (n = 5 in all groups). (*p = 0.085 by analysis of variance compared with normal left lung; **p = 0.002 by paired t test compared with matched right lung and p = 0.0001 by analysis of variance compared with normal left lung.) The Annals of Thoracic Surgery 1996 62, 866-872DOI: (10.1016/S0003-4975(96)00509-7) Copyright © 1996 The Society of Thoracic Surgeons Terms and Conditions

Fig. 6 Effect of allostimulation is not due to graft-versus-host disease. Similar large increases are seen in class II expression after allostimulation with either Lewis or Lewis X Brown Norway F1 mononuclear cells and 2 hours of ischemia followed by 9 days of reperfusion (n = 5 in all groups except where indicated). (*p = 0.0003 by analysis of variance compared with normal left lung; **p = 0.005 by paired t test over matched right lung and p < 0.0001 by analysis of variance compared with normal left lung.) The Annals of Thoracic Surgery 1996 62, 866-872DOI: (10.1016/S0003-4975(96)00509-7) Copyright © 1996 The Society of Thoracic Surgeons Terms and Conditions