Volume 2, Issue 2, Pages (August 2002)

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Volume 2, Issue 2, Pages 149-155 (August 2002) Telomere dysfunction provokes regional amplification and deletion in cancer genomes Rónán C O'Hagan, Sandy Chang, Richard S Maser, Ramya Mohan, Steven E Artandi, Lynda Chin, Ronald A DePinho Cancer Cell Volume 2, Issue 2, Pages 149-155 (August 2002) DOI: 10.1016/S1535-6108(02)00094-6

Figure 1 Late generation mTerc−/−,p53+/− cancer genomes exhibit significantly greater levels of genomic instability than early generation mTerc−/−,p53+/− tumors A: Histogram illustrates the frequency of BACs exhibiting copy number changes as determined by array-CGH. G0–G2 represents tumors from mTerc+/+,p53+/− and early generation mTerc−/−,p53+/− mice. G4–G7 represents tumors from late generation mTerc−/−,p53+/− mice. B: Table illustrates the frequency of BACs exhibiting copy number changes as determined by array-CGH for individual tumor types. Cancer Cell 2002 2, 149-155DOI: (10.1016/S1535-6108(02)00094-6)

Figure 2 Identification of the minimal amplicon on mouse chromosome 6 The extent of the region of amplification at distal chromosome 6 is indicated by the black bars for 13 mTerc−/−,p53+/− tumors that contained amplifications in this region. The name of the marker, and its position on chromosome 6 (defined by mouse genome database), are indicated in the upper part of the figure. Cancer Cell 2002 2, 149-155DOI: (10.1016/S1535-6108(02)00094-6)

Figure 3 Chromosomal alterations in tumors of mTerc−/−,p53+/− mice are homologous to human cancer hotspots Chromosomal locations of CNAs detected by array-CGH in breast (blue), skin (green), and colon (red) carcinomas in mTerc−/−,p53+/− mice. Gains are indicated by lines to the right of the chromosome ideograms, and losses are indicated by lines to the left. Numbers and arrows indicate the frequency with which the homologous region of a particular CNA was affected in the corresponding human tumor. Cancer Cell 2002 2, 149-155DOI: (10.1016/S1535-6108(02)00094-6)