Added value and cascade effects of inflammatory marker tests in UK primary care: a cohort study from the Clinical Practice Research Datalink by Jessica.

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Presentation transcript:

Added value and cascade effects of inflammatory marker tests in UK primary care: a cohort study from the Clinical Practice Research Datalink by Jessica Watson, Chris Salisbury, Penny Whiting, Jonathan Banks, Yvette Pyne, and Willie Hamilton BJGP Volume 69(684):e470-e478 June 27, 2019 ©2019 by British Journal of General Practice

Flowchart showing exclusions. Flowchart showing exclusions. CPRD = clinical practice research datalink. CRP = C-reactive protein. ESR = erythrocyte sedimentation rate. PV = plasma viscosity.aMatched untested consists of 39 928 subjects because, of the 40 000 from the cohort who were randomly selected for matching, 72 had no suitable age, sex, and practice-matched control. Jessica Watson et al. Br J Gen Pract 2019;69:e470-e478 ©2019 by British Journal of General Practice

Test implications flowchart. Test implications flowchart. Numbers and percentages do not add up to 100% due to rounding and because a small number of people developed more than one relevant disease outcome. Jessica Watson et al. Br J Gen Pract 2019;69:e470-e478 ©2019 by British Journal of General Practice

Incidence of relevant disease in relation to test result for CRP Incidence of relevant disease in relation to test result for CRP. CRP = C-reactive protein. Incidence of relevant disease in relation to test result for CRP. CRP = C-reactive protein. Jessica Watson et al. Br J Gen Pract 2019;69:e470-e478 ©2019 by British Journal of General Practice

Incidence of relevant disease in relation to test result for ESR Incidence of relevant disease in relation to test result for ESR. ESR = erythrocyte sedimentation rate. Incidence of relevant disease in relation to test result for ESR. ESR = erythrocyte sedimentation rate. Jessica Watson et al. Br J Gen Pract 2019;69:e470-e478 ©2019 by British Journal of General Practice

Incidence of relevant disease in relation to test result for PV Incidence of relevant disease in relation to test result for PV. PV = plasma viscosity. Incidence of relevant disease in relation to test result for PV. PV = plasma viscosity. For the small number (<0.5%) with one or more disease outcome; cancer superseded autoimmune disease, which superseded infections. Jessica Watson et al. Br J Gen Pract 2019;69:e470-e478 ©2019 by British Journal of General Practice