Gene delivery of ChABC leads to improved sensorimotor function and spinal conduction following spinal contusion. Gene delivery of ChABC leads to improved.

Slides:

Advertisements

Similar presentations

From: Nerve Injury-related Autoimmunity Activation Leads to Chronic Inflammation and Chronic Neuropathic Pain Anesthes. 2013;118(2): doi: /ALN.0b013e31827d4b82.

Advertisements

Pioglitazone treatment prevents TRPC6 overexpression and podocyte injury in the adriamycin (ADRIA)–induced nephropathy rat model for FSGS. ADRIA-induced.

Volume 18, Issue 1, Pages (January 2010)

Volume 64, Issue 2, Pages (October 2009)

Dendritic spine density at P30 is elevated on isolated PirB−/− neurons in layer 2/3 after sparse excision of PirB at E15.5. Dendritic spine density at.

Density of dendritic spines on L2/3 pyramidal neurons is greater in visual cortex of germline PirB−/− mice than in PirB+/+ mice at P30. Density of dendritic.

Volume 15, Issue 7, Pages (May 2016)

Oxalate handling for N. albigula in vivo for animals that completed the diet trial (n = 7). Oxalate handling for N. albigula in vivo for animals that completed.

Depletion of T cells, in particular CD8+ T cells, significantly abrogates HEV neogenesis in tumors. Depletion of T cells, in particular CD8+ T cells, significantly.

Fig. 7 Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors. Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors.

SNI causes a reduction in AIS length in the IL, an effect that is partially reversed by metformin. SNI causes a reduction in AIS length in the IL, an effect.

Surface renderings of the brain activation showing significant activation in the general mixed design ANOVA for the interaction between all three factors,

Volume 5, Issue 2, Pages (August 2015)

PERK activator treatment protects neurite network

Head orientation gates sensory responses.

Volume 18, Issue 4, Pages (April 2010)

Volume 25, Issue 12, Pages (December 2017)

Fig. 7 Improvement of clinical score and axon pathology by nasal IL-4 treatment during chronic EAE. Improvement of clinical score and axon pathology by.

Activation of PBN and CeA by illuminating the hindpaw after PNI

Volume 19, Issue 11, Pages (June 2009)

Synaptic transmission and plasticity is disturbed in 2-week-old but not in adult SynDIG1 β-gal mutant mice. Synaptic transmission and plasticity is disturbed.

Effects of early and late diabetic neuropathy on sciatic nerve block duration and neurotoxicity in Zucker diabetic fatty rats P. Lirk, C. Verhamme, R.

TRPV1 mediates Ca2+ flux and cytoskeletal fragmentation during trophic factor deprivation. TRPV1 mediates Ca2+ flux and cytoskeletal fragmentation during.

GlyR activation modulates its diffusion properties around active synapses. GlyR activation modulates its diffusion properties around active synapses. A,

Two-way ANOVA analysis of additive manufactured (AM) compared to titanium plasma spray (TPS) coated discs, with and without nanocrystalline hydroxyapatite.

Evidence for an Age-Dependent Decline in Axon Regeneration in the Adult Mammalian Central Nervous System Cédric G. Geoffroy, Brett J. Hilton, Wolfram.

Relative growth of WT R2866 and the R2866ΔampG gene deletion mutant with Triton X-100. Relative growth of WT R2866 and the R2866ΔampG gene deletion mutant.

Comparison of fecal metabolite concentrations in breast-fed (BF, green), standard formula-fed (FF, red), and B. lactis-supplemented formula-fed (FF + B.

Two-way ANOVA analysis of additive manufactured (AM) compared to titanium plasma spray (TPS) coated discs, with and without nanocrystalline hydroxyapatite.

Effects of embryonic hypoxia on fasted and postprandial cardiac output

Mean number of endoneurial and epineurial vessels per nerve in stumps at 48 h and 2 weeks after sciatic nerve transection. Mean number of endoneurial and.

Sleep deprivation by caffeine and mechanical disturbance of w1118 flies results in a decrease in egg output. Sleep deprivation by caffeine andmechanical.

CRISPRa sgRNA multiplexing for synergistic or coordinated control of gene expression. CRISPRa sgRNA multiplexing for synergistic or coordinated control.

A: Total number of neurons in L5 dorsal root ganglia of long-term diabetic, recovered, and nondiabetic mice. A: Total number of neurons in L5 dorsal root.

Presynaptic OSN GABA receptors accelerate behavioral responses to odor pulse termination. Presynaptic OSN GABA receptors accelerate behavioral responses.

Results of CFC training and testing.

Peli1 levels are reduced in bid−/− microglia upon LPS stimulation.

Diclofenac treatment reduces L-selectin on peripheral blood and infiltrated leukocytes but does not alter accumulation in the injured spinal cord. Diclofenac.

Phosphorylated CREB levels were assessed in the hippocampus at 20 min after cue and contextual fear conditioning. Phosphorylated CREB levels were assessed.

Loss of ATF3 function modestly reduces axonal regeneration following sciatic nerve crush. Loss of ATF3 function modestly reduces axonal regeneration following.

Intraperitoneal injection of tBHQ reduced sensorimotor deficit and stroke damage 24 h after ischemia-reperfusion. Intraperitoneal injection of tBHQ reduced.

Loss of Nrf2 function in vivo increased cortical damage after permanent focal ischemia. Loss of Nrf2 function in vivo increased cortical damage after permanent.

Mice fed GP-SPI diet show improved fasting glucose and oral glucose tolerance. Mice fed GP-SPI diet show improved fasting glucose and oral glucose tolerance.

Microglia activation in distinct sites of the spinal cord from mice with bronchial asthma or atopic dermatitis on the back skin at the thoracic spinal.

Chronic SSRI treatment rescued lOFC hyperactivity in QNP-treated mice.

MCM and ACM treatment of acutely isolated MNs results in differential caspase activation and utilization. MCM and ACM treatment of acutely isolated MNs.

Tactile allodynia with activation of dorsal horn neuron in atopy model mice. Tactile allodynia with activation of dorsal horn neuron in atopy model mice.

Interference of Kv4 in dorsal neurons (DN1s) does not significantly regulate sleep onset. Interference of Kv4 in dorsal neurons (DN1s) does not significantly.

Gene delivery of ChABC leads to reduced neuronal death associated with lower levels of apoptosis at 1 week postinjury. Gene delivery of ChABC leads to.

Bar chart of the mean densities of immunopositive axons displaying caspase-linked SBDP-120- immunoreactivity in the CSpT (black) and the MLF (gray) at.

Effect of PPARγ agonist on Aβ phagocytosis in primary microglia.

NRG1 activates cortical erbB4 receptors and increases excitation onto PV+ interneurons. NRG1 activates cortical erbB4 receptors and increases excitation.

Transgenic expression of mCREB or CREB produces opposite effects in the learned helplessness model of depression. Transgenic expression of mCREB or CREB.

Peripheral surgery regulates expression of astrocytic markers.

The developmental spine morphology changes predict decreased biochemical compartmentalization with age, while loss of FMRP subtly influences this in an.

Astroglial activation in distinct sites of the spinal cord from mice with bronchial asthma or atopic dermatitis on the back skin at the thoracic spinal.

A, B, Startle magnitude and PPI after treatment with CNO

Minocycline treatment inhibited dorsal column transection-induced glial cell death within the distal and proximal AST. A, Percentage of apoptotic microglia/macrophages.

NPC-derived oligodendrocytes are maintained long term after cuprizone challenge. NPC-derived oligodendrocytes are maintained long term after cuprizone.

MET-1 increases DRG neuron K+ currents.

Exposure of in vitro sensorimotor synaptic connections to RNA from trained animals enhanced the strength of a subpopulation of synapses. Exposure of in.

Comparison between YFP-based and APP-labeled axonal lesions with CLARITY at 3 and 24 h after injury. Comparison between YFP-based and APP-labeled axonal.

Intra-amygdala MPEP is analgesic during bladder distention.

Cytokine expression in the ileum and colon.

FKBP1b counters the age-related decrease in hippocampal MAP2 protein expression. FKBP1b counters the age-related decrease in hippocampal MAP2 protein expression.

SIRT1 deletion exacerbates premature lethality and synapse loss in tauP301S mice. SIRT1 deletion exacerbates premature lethality and synapse loss in tauP301S.

Neutralization of CSF1 and Ad5-HRG treatment.

Removal of the PNNs affect LFP oscillations during spontaneous activity, but not during stimulus-evoked activity. Removal of the PNNs affect LFP oscillations.

Subodh Verma et al. BTS 2018;3:

Time courses of octreotide (OCT) concentrations depended on sodium bisulfate (SBS) concentrations. Time courses of octreotide (OCT) concentrations depended.

Presentation transcript:

Gene delivery of ChABC leads to improved sensorimotor function and spinal conduction following spinal contusion. Gene delivery of ChABC leads to improved sensorimotor function and spinal conduction following spinal contusion. A, Impact data showing the actual force applied to individual animals was within 10% of the intended force of 150 kdyne and mean values for each group were not significantly different (n = 14 per group; p > 0.05; 1-way ANOVA), confirming that any group differences were not due to differences in the impact force during surgery. B, Treatment with LV-ChABC leads to an early and sustained improvement in sensorimotor function, as shown by a significant reduction in footslips on the horizontal ladder task at all postinjury time points compared with contusion only and contusion plus LV-GFP treatment; p < 0.01, two-way repeated-measures ANOVA, Bonferroni's post hoc). C, Following treatment with LV-ChABC, there is a significant improvement in the percentage of sensory dorsal column axons that are capable of conducting through the injury site at a chronic (10 weeks) postinjury time point (p < 0.01, 1-way ANOVA, Tukey's post hoc). D, Example traces of recordings. Katalin Bartus et al. J. Neurosci. 2014;34:4822-4836 ©2014 by Society for Neuroscience