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Volume 3, Issue 5, Pages 412-415 (September 2017) Complete pathologic response of metastatic cutaneous squamous cell carcinoma and allograft rejection after treatment with combination immune checkpoint blockade David M. Miller, MD, PhD, Beverly E. Faulkner-Jones, MD, PhD, James R. Stone, MD, PhD, Reed E. Drews, MD JAAD Case Reports Volume 3, Issue 5, Pages 412-415 (September 2017) DOI: 10.1016/j.jdcr.2017.06.005 Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Punch biopsy of scalp recurrence shows myxoid spindle cell SCC. (Hematoxylin-eosin stain; low power). A high-resolution version of the image is available as eSlide: https://slide-atlas.org/link/mx4sax. JAAD Case Reports 2017 3, 412-415DOI: (10.1016/j.jdcr.2017.06.005) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Computed tomography scan of the chest without contrast before starting ipi/nivo. Numerous pulmonary metastases can be seen. JAAD Case Reports 2017 3, 412-415DOI: (10.1016/j.jdcr.2017.06.005) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Computed tomography scan of the chest with contrast after 4 cycles of ipi/nivo. Significant decrease in the size and number of pulmonary metastases is noted compared with the pretreatment scan. JAAD Case Reports 2017 3, 412-415DOI: (10.1016/j.jdcr.2017.06.005) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 4 Right upper lobe lung nodule acquired at necropsy. Tissue did not contain any neoplastic cells or organisms and was consistent with treated malignancy. Another 1-cm necrotic lung nodule in the left upper lobe was identified at necropsy and was most consistent with treated mcSCC. JAAD Case Reports 2017 3, 412-415DOI: (10.1016/j.jdcr.2017.06.005) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions