A CRF1, but not CRF2, receptor antagonist inhibits pain-related behavior in animals with arthritis but not in normal animals. A CRF1, but not CRF2, receptor.

Slides:

Advertisements

Similar presentations

1)Action Potential in Motor Axon 2) End Plate Potential at Neuromuscular Junction 3) Action Potential in Muscle Fiber. 4) The AP induces, after a small.

Advertisements

Long-term analgesic effect of a single dose of anti-NGF antibody on pain during motion without notable suppression of joint edema and lesion in a rat.

Volume 62, Issue 4, Pages (October 2012)

Kurt C. Marsden, Michael Granato Cell Reports

Inhibition of cyclooxygenase 2 expression by diallyl sulfide on joint inflammation induced by urate crystal and IL-1β H.-S. Lee, M.D., Ph.D., C.-H. Lee,

Halothane potentiates the effect of methamphetamine and nomifensine on extracellular dopamine levels in rat striatum: a microdialysis study Y.U. Adachi,

Volume 139, Issue 5, Pages (November 2009)

Role of Glutamate Autoreceptors at Hippocampal Mossy Fiber Synapses

Interactions between Distinct GABAA Circuits in Hippocampus

The relationship between dorsal horn neurotransmitter content and allodynia in neuropathic rats treated with high-frequency transcutaneous electric nerve.

Intra-articular nerve growth factor regulates development, but not maintenance, of injury-induced facet joint pain & spinal neuronal hypersensitivity

Modulation Between High- and Low-Frequency Transcutaneous Electric Nerve Stimulation Delays the Development of Analgesic Tolerance in Arthritic Rats

Gregory Wynn, Weifang Rong, Zhenghua Xiang, Geoffrey Burnstock

Volume 58, Issue 3, Pages (May 2008)

Blockade of nociceptive sensory afferent activity of the rat knee joint by the bradykinin B2 receptor antagonist fasitibant A. Gomis, S. Meini, A. Miralles,

Differences in structural and pain phenotypes in the sodium monoiodoacetate and meniscal transection models of osteoarthritis P.I. Mapp, D.R. Sagar,

Urethane reduces the frequency of spontaneous recurrent seizures six to eight weeks following 1 h of DFP-induced SE. A, Cortical EEG activity was recorded.

MN-enriched miRNAs are depleted temporally in ALS rodent model and human patient spinal cord. MN-enriched miRNAs are depleted temporally in ALS rodent.

Activation of PBN and CeA by illuminating the hindpaw after PNI

Volume 22, Issue 4, Pages (April 1999)

Volume 139, Issue 5, Pages (November 2009)

Two Directions of Plasticity in the Sensory-Deprived Adult Cortex

Dopamine-Dependent Interactions between Limbic and Prefrontal Cortical Plasticity in the Nucleus Accumbens: Disruption by Cocaine Sensitization Yukiori.

Bar graph of the number of averaged activated voxels (normalized to control values), as defined by increases in lactate concentration in the left frontal.

Effect of optogenetic inhibition of D2-MSNs or D1-MSNs in the VLS on goal-directed behavior in mice. Effect of optogenetic inhibition of D2-MSNs or D1-MSNs.

Jennifer A Cummings, Rosel M Mulkey, Roger A Nicoll, Robert C Malenka

Depolarization-induced postsynaptic NT secretion depends on Ca2+ influx. Depolarization-induced postsynaptic NT secretion depends on Ca2+ influx. Hippocampal.

Selective modulation of AMPAR-mediated transmission in 4E-BP2−/− mice.

Effect of varying frequency, intensity, and pulse duration of transcutaneous electrical nerve stimulation on primary hyperalgesia in inflamed rats Priya.

Characterization of non-DA firing.

Results of CFC training and testing.

Basal synaptic transmission and climbing fiber activity remained intact in PNs of STIM1PKO mice. Basal synaptic transmission and climbing fiber activity.

Propagation is independent of synaptic transmission.

Experimental paradigm.

CIE does not alter D2/D4 receptor expression in the mPFC.

Effect of circadian forced desynchrony on sexual behavior of male rats during the dark phase. Effect of circadian forced desynchrony on sexual behavior.

Mek-1/2 activity mediates stress-enhanced Erk-1/2 phosphorylation and fear conditioning. Mek-1/2 activity mediates stress-enhanced Erk-1/2 phosphorylation.

Adult scent marking and open-field activity in the presence of female urine. Adult scent marking and open-field activity in the presence of female urine.

NRG1 depolarizes action potential threshold.

Effect of circadian forced desynchrony on behavioral manifestations of depression. Effect of circadian forced desynchrony on behavioral manifestations.

Effect of IBMP and PKG on cAMP levels

Spinal application of naloxone did not change population responses of superficial and deep WDR neurons to graded intracutaneous electrical stimuli in wild-type.

Blockade of the Nogo receptor NgR1 enhances LTP in the rat primary motor cortex. Blockade of the Nogo receptor NgR1 enhances LTP in the rat primary motor.

Subcategorical structure within animate and inanimate categories in TEO, TE, and PFC. a, The bar graphs show the mean dissimilarities (percentile of 1.

LFP findings from the PPC during performance on the visual target-detection task. LFP findings from the PPC during performance on the visual target-detection.

Closed-loop experiments to probe the range of stimulus sensitivity.

Effects of vocal motor production upon sensory responses.

Effects of an AMPA receptor antagonist on numbers of pCofilin-positive spines. Effects of an AMPA receptor antagonist on numbers of pCofilin-positive spines.

Squid mechanoafferents show rapid sensitization after noxious stimulation of the excised fin. Squid mechanoafferents show rapid sensitization after noxious.

The developmental spine morphology changes predict decreased biochemical compartmentalization with age, while loss of FMRP subtly influences this in an.

Glycogen content of rat optic nerves after glucose deprivation and pharmacological manipulation. Glycogen content of rat optic nerves after glucose deprivation.

A, Elevation in the amount of solution consumed (without sucrose or salt) during the depletion test following sodium depletion compared with the baseline.

Activation of microglial group III mGlu receptors inhibits the release of soluble, stable neurotoxins. Activation of microglial group III mGlu receptors.

Enrichment of mononucleosomes and oligonucleosomes in the cytoplasmic fraction after a 6.25 mm injury (enrichment factor, absorbance of the injured tissue/absorbance.

FMRP S499 rephosphorylation kinetics after CX-4945 treatment and washout mirrors a known CK2 target. FMRP S499 rephosphorylation kinetics after CX-4945.

CPARs in the NAc protect against depression-like behaviors induced by chronic pain. CPARs in the NAc protect against depression-like behaviors induced.

Cue-evoked dopamine release dynamics in the NAc shell and core.

Intra-amygdala DHPG results in bladder hyperalgesia.

Intra-amygdala MPEP is analgesic during bladder distention.

Entrainment of spiny neurons into antidromic stimulation is robust and time dependent. Entrainment of spiny neurons into antidromic stimulation is robust.

Firing rate during consummatory behavior at the early training time point. Firing rate during consummatory behavior at the early training time point. Cells.

SSC LTP in narrow-field vertical neurons is induced by SO stimulation at 20 Hz for 20 s. sSC LTP in narrow-field vertical neurons is induced by SO stimulation.

Shank3 homozygous mice exibited impairment in synaptic transmission, induction, and maintenance of long-term potentiation. Shank3 homozygous mice exibited.

Binocular neurons mismatched in spatial frequency are also mismatched in orientation preference. Binocular neurons mismatched in spatial frequency are.

Optogenetically stimulated Aβ fibers induce pain-like behaviors after PNI. A, B, Withdrawal score by light (A) and paw withdrawal threshold by von Frey.

Synaptic depression in principal neurons of the rat MNTB

Removal of the PNNs affect LFP oscillations during spontaneous activity, but not during stimulus-evoked activity. Removal of the PNNs affect LFP oscillations.

Partial restoration of impaired LTP in hippocampal slices from 12-month-old NCAM−/− mice through inhibition of GluN2B-containing receptor signaling. Partial.

The effect of roscovitine on Ca2+-dependent glutamate release from synaptosomes prepared from rat brains in response to membrane depolarization with 1.

The DOR agonist DPDPE evokes and occludes I-LTD.

Presentation transcript:

A CRF1, but not CRF2, receptor antagonist inhibits pain-related behavior in animals with arthritis but not in normal animals. A CRF1, but not CRF2, receptor antagonist inhibits pain-related behavior in animals with arthritis but not in normal animals. Audible (A, B) and ultrasonic (C, D) vocalizations and spinal withdrawal reflexes (E, F) were measured in two groups of animals: normal (left side in each graph) and arthritis (right side). In the normal group, behaviors were measured before (baseline) and during (15–20 min) drug application into the CeA by microdialysis. In the arthritis group, behaviors were measured before (baseline) and 6 h after arthritis induction and during (15–20 min) and after (30 min washout) drug application into the CeLC in the arthritis state. Vocalizations were evoked by brief (15 s) noxious (2000 g/30 mm2) stimulation of the knee with a calibrated forceps. Duration of vocalizations was measured as the arithmetic sum of the duration of each individual vocalization event during a 1 min period beginning with the onset of the mechanical stimulus as described previously (Han et al., 2005a; Neugebauer et al., 2007). A, NBI27914 (NBI, 50 μm, concentration in the microdialysis fiber) had no effect on audible vocalizations in normal animals (n = 5) but inhibited the increased vocalizations of arthritic rats significantly (n = 11, p < 0.001, Newman–Keuls multiple comparison test). B, Astressin-2B (50 μm, concentration in the microdialysis probe) did not affect audible vocalizations in normal rats (n = 6) and in arthritic rats (n = 6). C, NBI27914 had no significant effect on ultrasonic vocalizations of normal rats (n = 5) but inhibited the increased ultrasonic vocalizations of arthritic rats (n = 11, p < 0.01, Newman–Keuls multiple comparison test). D, Astressin-2B had no significant effect on ultrasonic vocalizations of normal rats (n = 6) and arthritic rats (n = 6). E, NBI27914 had no significant effect on hindlimb-withdrawal reflex thresholds in normal rats but increased the withdrawal thresholds of arthritic rats (n = 11, p < 0.01, Newman–Keuls multiple comparison test). F, Astressin-2B had no significant effect in arthritic animals (n = 6) and under normal conditions (n = 6). Hindlimb-withdrawal thresholds were measured by applying pressure of increasing force to the knee joint with a calibrated forceps. Bar histograms and error bars represent mean ± SE. **p < 0.01, ***p < 0.001. Yu Fu, and Volker Neugebauer J. Neurosci. 2008;28:3861-3876 ©2008 by Society for Neuroscience