Spontaneous and strong Tfh cell but not Tfr cell development in IL-2 KO mice. Spontaneous and strong Tfh cell but not Tfr cell development in IL-2 KO mice.

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Spontaneous and strong Tfh cell but not Tfr cell development in IL-2 KO mice. Spontaneous and strong Tfh cell but not Tfr cell development in IL-2 KO mice. Naive 10-wk-old WT and IL-2 KO mice were used to analyze Tfh and Tfr responses. Spleens were analyzed for the indicated cell populations by flow cytometry. Representative flow cytometric dot plots for each cell stain are shown along with graphs showing average percentage of cells as a fraction of parental cell population and total yield of cells. (A and B) Analysis of CD4+ Foxp3−T cells as PD-1+Cxcr5−, PD-1+Cxcr5+ (Tfh), PD-1−Cxcr5+, and PD-1−Cxcr5− populations. (B) Tfh cells and non-Tfh cell populations are quantitated as a percentage of CD4+Foxp3− T cells and absolute number per spleen. (C and D) Analysis of CD4+ Foxp3+T cells as PD-1+Cxcr5−, PD-1+Cxcr5+ (Tfr), PD-1−Cxcr5+, and PD-1−Cxcr5− populations. (D) Tfr cells are quantitated as a percentage of CD4+Foxp3+ T cells and absolute number per spleen. n = 4–6 mice, and each experiment was repeated two times. The p values were calculated by t test, in which *p < 0.05, ***p < 0.0001. Markus M. Xie et al. ImmunoHorizons 2019;3:306-316 Copyright © 2019 The Authors